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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism.
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Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism.

机译：基于体素的MRI分析显示，由于恐怖主义造成的创伤后应激障碍的前扣带回灰质体积减小。

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MRI studies using the manual tracing method have shown a smaller-than-normal hippocampal volume in patients with posttraumatic stress disorder (PTSD). However, these studies have yielded inconsistent results, and brain structures other than the hippocampus have not been well investigated. A recently developed, fully automated method called voxel-based morphometry enables an exploration of structural changes throughout the brain by applying statistical parametric mapping to high-resolution MRI. Here we first used this technology in patients with PTSD. Participants were 9 victims of the Tokyo subway sarin attack with PTSD and 16 matched victims of the same traumatic event without PTSD. The voxel-based morphometry showed a significant gray-matter volume reduction in the left anterior cingulate cortex (ACC) in trauma survivors with PTSD compared with those without PTSD. The severity of the disorder was negatively correlated with the gray-matter volume of the left ACC in PTSD subjects. There were no significant differences in other gray-matter regions or any of the white-matter regions between two groups. The present study demonstrates evidence for structural abnormalities of ACC in patients with PTSD. Together with previous functional neuroimaging studies showing a dysfunction of this region, the present findings provide further support for the important role of ACC, which is pivotally involved in attention, emotional regulation, and conditioned fear, in the pathology of PTSD.
机译：使用手动追踪方法进行的MRI研究显示，创伤后应激障碍（PTSD）患者的海马体积比正常情况小。但是，这些研究得出的结果不一致，对海马以外的大脑结构尚未进行充分的研究。一种最新开发的，称为基于体素的形态计量学的全自动方法，通过将统计参数映射应用于高分辨率MRI，可以探索整个大脑的结构变化。在这里，我们首先在PTSD患者中使用了这项技术。参与者是9名在东京地铁沙林袭击中与PTSD遇难的受害者，以及16名在没有PTSD的同一创伤事件中相匹配的受害者。基于体素的形态计量学显示，与没有PTSD的创伤幸存者相比，创伤幸存者的左前扣带回皮质（ACC）的灰质体积明显减少。该疾病的严重程度与PTSD患者左ACC的灰质体积呈负相关。两组之间的其他灰质区域或任何白质区域没有显着差异。本研究证明了PTSD患者ACC结构异常的证据。与以前的功能性神经影像学研究一起显示该区域的功能障碍，目前的发现为ACC的重要作用提供了进一步的支持，ACC的重要作用是在PTSD的病理中涉及注意力，情绪调节和条件性恐惧。

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