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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A pancreatic β-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes
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A pancreatic β-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes

机译：胰岛β细胞特异性葡萄糖6-磷酸酶的同源物成为糖尿病中细胞介导的自身免疫的主要靶标

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摘要

Diabetes has been termed the epidemic of the 21st century and over the past 50 years in Western societies has been doubling in incidence every 15 years. It exacts a huge socioeconomic toll because of its devastating microvascular and macrovascular complications and the need of patients to maintain a lifetime daily therapeutic regimen. The childhood-onset form of diabetes, which accounts for 10% of all cases in humans [autoimmune or type 1 diabetes (IDDM)], is the product of a T lymphocyte-dependent autoimmune process that specifically destroys the insulin-secreting β cells of the pancreas without affecting contiguous endocrine cells or the surrounding exocrine tissue. Such tissue and cell specificity might logically be the product of an autoimmune reactivity directed at β-cell-specific molecular targets mediated by direct cellular contact between the target β cell and effector cytotoxic T lymphocytes.
机译：糖尿病被称为21世纪的流行病，在过去的50年中，西方社会的发病率每15年翻一番。由于其破坏性的微血管和大血管并发症以及患者维持终生日常治疗方案的需要，它造成了巨大的社会经济损失。糖尿病是儿童期的发病形式，占人类所有病例的10％[自身免疫或1型糖尿病（IDDM）]，是T淋巴细胞依赖性自身免疫过程的产物，该过程特异性破坏了胰岛素分泌性β细胞。胰腺而不会影响连续的内分泌细胞或周围的外分泌组织。在逻辑上，这种组织和细胞特异性可能是针对β细胞特异性分子靶标的自身免疫反应性的产物，该靶标是通过靶β细胞与效应细胞毒性T淋巴细胞之间的直接细胞接触而介导的。

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