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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain
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The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain

机译：LIM-homeobox基因Lhx8是小鼠前脑中许多胆碱能神经元发育所必需的

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摘要

Forebrain cholinergic neurons play important roles as striatal local circuit neurons and basal telencephalic projection neurons. The genetic mechanisms that control development of these neurons suggest that most of them are derived from the basal telencephalon where Lhx8, a LIM-homeobox gene, is expressed. Here we report that mice with a null mutation of Lhx8 are deficient in the development of forebrain cholinergic neurons. Lhx8 mutants lack the nucleus basalis, a major source of the cholinergic input to the cerebral cortex. In addition, the number of cholinergic neurons is reduced in several other areas of the subcortical forebrain in Lhx8 mutants, including the caudate-putamen, medial septal nucleus, nucleus of the diagonal band, and magnocellular preoptic nucleus. Although cholinergic neurons are not formed, initial steps in their specification appear to be preserved, as indicated by a presence of cells expressing a truncated Lhx8 mRNA and mRNA of the homeobox gene Gbx1. These results provide genetic evidence supporting an important role for Lhx8 in development of cholinergic neurons in the forebrain. [References: 42]
机译：前脑胆碱能神经元作为纹状体局部回路神经元和基底端脑投射神经元发挥重要作用。控制这些神经元发育的遗传机制表明，它们大多数来自基底端脑，其中Lhx8是一种LIM同源盒基因。在这里我们报告具有Lhx8无效突变的小鼠在前脑胆碱能神经元的发育中缺乏。 Lhx8突变体缺乏基底核，这是向大脑皮层提供胆碱能的主要来源。此外，Lhx8突变体的皮质前脑其他几个区域的胆碱能神经元数量减少，包括尾状-丘脑，内侧中隔核，对角带状核和视细胞前视神经核。尽管未形成胆碱能神经元，但其规格中的初始步骤似乎得以保留，如存在表达截短的Lhx8 mRNA和同源盒基因Gbx1 mRNA的细胞所表明的。这些结果提供了遗传证据，支持Lhx8在前脑胆碱能神经元发育中的重要作用。 [参考：42]

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