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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain.
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Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain.

机译：成年人类亨廷顿舞蹈病大脑中细胞增殖和神经发生的增加。

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Neurogenesis has recently been observed in the adult human brain, suggesting the possibility of endogenous neural repair. However, the augmentation of neurogenesis in the adult human brain in response to neuronal cell loss has not been demonstrated. This study was undertaken to investigate whether neurogenesis occurs in the subependymal layer (SEL) adjacent to the caudate nucleus in the human brain in response to neurodegeneration of the caudate nucleus in Huntington's disease (HD). Postmortem control and HD human brain tissue were examined by using the cell cycle marker proliferating cell nuclear antigen (PCNA), the neuronal marker betaIII-tubulin, and the glial cell marker glial fibrillary acidic protein (GFAP). We observed a significant increase in cell proliferation in the SEL in HD compared with control brains. Within the HD group, the degree of cell proliferation increased with pathological severity and increasing CAG repeats in the HD gene. Most importantly, PCNA+ cells were shown to coexpress betaIII-tubulin or GFAP, demonstrating the generation of neurons and glial cells in the SEL of the diseased human brain. Our results provide evidence of increased progenitor cell proliferation and neurogenesis in the diseased adult human brain and further indicate the regenerative potential of the human brain.
机译：最近在成年人类大脑中观察到神经发生，提示内源性神经修复的可能性。然而，尚未证明响应于神经元细胞损失的成年人大脑中神经发生的增强。这项研究的目的是调查在亨廷顿舞蹈病（HD）中尾状核的神经退行性变是否在人脑中靠近尾状核的室管膜下层（SEL）发生神经发生。使用细胞周期标记增殖细胞核抗原（PCNA），神经元标记βIII-微管蛋白和神经胶质细胞标记神经胶质原纤维酸性蛋白（GFAP）检查死后对照和HD人类大脑组织。我们观察到，与对照组相比，HD的SEL细胞增殖明显增加。在HD组中，细胞增殖程度随HD基因的病理严重程度和CAG重复次数的增加而增加。最重要的是，显示PCNA +细胞与βIII-微管蛋白或GFAP共表达，这证明了患病人脑SEL中神经元和神经胶质细胞的生成。我们的结果提供了在患病的成年人脑中增加祖细胞增殖和神经发生的证据，并进一步表明了人脑的再生潜力。

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