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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.
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Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.

机译：感觉神经元特异性Mrg G蛋白偶联受体家族在小鼠中的非典型扩增。

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摘要

The Mas-related genes (Mrgs) comprise a family of >50 G protein-coupled receptors (GPCRs), many of which are expressed in specific subsets of nociceptive sensory neurons in mice. In contrast, humans contain a related but nonorthologous family of genes, called MrgXs or sensory neuron-specific receptors, of which many fewer appear to be expressed in sensory neurons. To determine whether the diversity of murine Mrgs is generic to rodents or is an atypical feature of mice, we characterized MrgA, MrgB, MrgC, and MrgD subfamilies in rat and gerbil. Surprisingly, although mice have approximately 22 MrgA and approximately 14 MrgC genes, rats and gerbils have just a single MrgA and MrgC gene. This murine-specific expansion likely reflects recent retrotransposon-mediated unequal crossover events. The expression of Mrgs in rat sensory ganglia suggests that the extensive cellular diversity in mice can be simplified to a core subset of approximately four different genes (MrgA, MrgB, MrgC, and MrgD), defining a similar number of neuronal subpopulations. Our results suggest more generally that mouse-human genomic comparisons may sometimes reveal differences atypical of rodents.
机译：Mas相关基因（Mrgs）包含> 50 G蛋白偶联受体（GPCR）家族，其中许多在小鼠伤害性感觉神经元的特定子集中表达。相比之下，人类包含一个相关但非直系同源的基因家族，称为MrgXs或感觉神经元特异性受体，其中似乎在感觉神经元中表达的基因更少。为了确定鼠Mrgs的多样性是啮齿动物所共有还是小鼠的非典型特征，我们对大鼠和沙鼠中的MrgA，MrgB，MrgC和MrgD亚科进行了特征分析。出乎意料的是，尽管小鼠具有约22个MrgA和约14个MrgC基因，但是大鼠和沙鼠仅具有单个MrgA和MrgC基因。这种鼠特异性的扩增可能反映了最近反转录转座子介导的不平等交换事件。 Mrgs在大鼠感觉神经节中的表达表明，小鼠中广泛的细胞多样性可以简化为大约四个不同基因（MrgA，MrgB，MrgC和MrgD）的核心子集，从而定义了相似数量的神经元亚群。我们的结果更普遍地表明，小鼠与人的基因组比较有时可能会揭示出啮齿类动物的非典型差异。

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