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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data
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Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data

机译：通过基因组和蛋白质组学数据的抗原分析鉴定恶性疟原虫抗原

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摘要

The recent explosion in genomic sequencing has made available a wealth of data that can now be analyzed to identify protein antigens, potential targets for vaccine development. Here we present, in the context of Plasmodium falciparum, a strategy that rapidly identifies target antigens from large and complex genomes. Sixteen antigenic proteins recognized by volunteers immunized with radiation-attenuated P. faiciparum sporozoites, but not by mock immunized controls, were identified. Several of these were more antigenic than previously identified and well characterized P. faiciparum-derived protein antigens. The data suggest that immune responses to Plasmodium are dispersed on a relatively large number of parasite antigens. These studies have implications for our understanding of immunodominance and breadth of responses to complex pathogens. [References: 39]
机译：基因组测序的最新发展提供了丰富的数据，现在可以对这些数据进行分析以鉴定蛋白质抗原，这是疫苗开发的潜在靶标。在这里，我们介绍了恶性疟原虫的背景下，可以从大型和复杂的基因组中快速识别靶抗原的策略。鉴定了十六种抗原蛋白，这些抗原被用辐射减毒的P. faiciparum子孢子免疫的志愿者识别，但未被模拟免疫的对照免疫。这些中的几个比以前鉴定出的和特征明确的源自费氏疟原虫的蛋白抗原更具抗原性。数据表明，对疟原虫的免疫反应分散在相对大量的寄生虫抗原上。这些研究对我们对免疫原性和对复杂病原体的反应广度的理解具有启示意义。 [参考：39]

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