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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Advantages of external periodic events to the evolution of biochemical oscillatory reactions.
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Advantages of external periodic events to the evolution of biochemical oscillatory reactions.

机译：外部周期性事件对生化振荡反应演化的优势。

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摘要

We compare, by calculations on a simple model of glycolysis, the evolutionary development of oscillatory reaction mechanisms in the presence and absence of external periodic events, such as an oscillatory or constant influx of glucose in an open reaction system. The chosen model has autonomous oscillations for given choices of the parameters of the feedback loops responsible for the oscillations, and for a given range of the total adenylate pool concentration. We change first one, then two of the parameters, so that there are no autonomous oscillations, and then vary these parameters with a genetic algorithm method in which the parameters are represented by binary strings that evolve by selection, crossover, and mutations; the optimization goal is the attainment of a high ATP/ADP concentration ratio in the system. This goal is taken to provide evolutionary advantages and is shown to be achieved more quickly in the presence of external periodic events, rather than constant influx of glucose. The resultssuggest the possibility of the enhanced evolutionary development of oscillatory biological reactions at shores where waves impinge on rocks and bring nutrients periodically. Measurements have shown that animals and plants grow more rapidly in the presence of such wave action than in its absence.
机译：通过对糖酵解的简单模型进行计算，我们比较了存在和不存在外部周期性事件（例如开放式反应系统中葡萄糖的振荡或恒定流入）的振荡反应机制的进化发展。对于给定的负责振荡的反馈回路的参数的给定选择以及总腺苷酸池浓度的给定范围，所选模型具有自主振荡。我们先更改一个参数，然后再更改两个参数，这样就不会出现自发振荡，然后使用遗传算法方法更改这些参数，在该算法中，参数由通过选择，交叉和突变演化的二进制字符串表示；优化目标是在系统中达到较高的ATP / ADP浓度比。该目标旨在提供进化优势，并且在存在外部周期性事件而不是不断流入葡萄糖的情况下，可以更快地实现。结果表明，在波浪撞击岩石并定期带入营养素的海岸上，振荡生物反应的增强进化发展的可能性。测量表明，在存在这种波动的情况下，动植物的生长比在没有波动的情况下动植物的生长更快。

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