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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Molecular imaging with endogenous substances.
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Molecular imaging with endogenous substances.

机译：内源性物质的分子成像。

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摘要

Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as 13C and 15N in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond 13C MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was obtained in an aqueous solution of 100 mM 13C-labeled urea, ready for injection. The in vivo T1 relaxation time of 13C in the urea solution was determined to 20 +/- 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution ( approximately 1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized aqueous [13C]urea solution in a rat. The results show that it is possible to perform 13C angiography with a signal-to-noise ratio of approximately 275 in approximately 0.25 s. Perfusion studies with endogenous substances may allow higher spatial and/or temporal resolution than is possible with current proton imaging techniques.
机译：动态核极化已使内源性物质中的13C和15N等核超极化。由此产生的高核极化可以执行亚秒级13C MRI。通过使用动态核极化超极化技术，在准备注射的100 mM 13C标记的尿素水溶液中获得了10％的极化。测定尿素溶液中13℃的体内T1弛豫时间为20 +/- 2s。由于弛豫时间长，可以将超极化物质用于医学成像。采集了一系列高分辨率（约1毫米）磁共振图像，每幅图像的扫描时间为240毫秒，在静脉输注后0-5 s。在大鼠中注射超极化[13C]尿素水溶液。结果表明，可以在大约0.25 s内以大约275的信噪比执行13C血管造影。与当前质子成像技术相比，内源性物质的灌注研究可以提供更高的空间和/或时间分辨率。

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