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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Chronic, multisite, multielectrode recordings in macaque monkeys
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Chronic, multisite, multielectrode recordings in macaque monkeys

机译：猕猴的慢性，多部位，多电极记录

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摘要

A paradigm is described for recording the activity of single cortical neurons from awake, behaving macaque monkeys. Its unique features include high-density microwire arrays and multichannel instrumentation. Three adult rhesus monkeys received microwire array implants, totaling 96-704 microwires per subject, in up to five cortical areas, sometimes bilaterally. Recordings 3-4 weeks after implantation yielded 421 single neurons with a mean peak-to-peak voltage of 115 +/- 3 muV and a signal-to-noise ratio of better than 5:1. As many as 247 cortical neurons were recorded in one session, and at least 58 neurons were isolated from one subject 18 months after implantation. This method should benefit neurophysiological investigation of learning, perception, and sensorimotor integration in primates and the development of neuroprosthetic devices. [References: 28]
机译：描述了一种范例，用于记录清醒的猕猴的单个皮质神经元的活动。它的独特功能包括高密度微线阵列和多通道仪器。三只成年恒河猴在多达五个皮质区域（有时是双侧）接受了微线阵列植入物，每个受试者总共植入96-704根微线。植入后3-4周的记录产生了421个单神经元，平均峰峰电压为115 +/- 3μV，信噪比优于5：1。在一个疗程中记录了多达247个皮质神经元，植入后18个月从一名受试者中分离出至少58个神经元。这种方法应该有利于对灵长类动物的学习，知觉和感觉运动整合以及神经修复装置的发展进行神经生理学研究。 [参考：28]

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