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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture
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Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture

机译：火箭筒和星尘在果蝇感光膜结构规范中的不同作用

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摘要

Photoreceptors form during Drosophila pupal development and acquire elaborate membrane structures, including the rhab-domeres and stalk membranes. Here, we show that the development of these cellular structures involves two distinct processes: the establishment of apical-basal polarity that requires Bazooka (Baz), and the regionalization of apical membrane into stalk membranes and rhabdomeres that requires Stardust (Sdt), In the absence of Baz, the apical-basal polarity is compromised in early pupal photoreceptors, and no identifiable apical membrane domain is formed. Sdt, in contrast, plays a more limited role in apical-basal polarity but is essential for the proper localization of transmembrane protein Crumbs (Crb), known to be required in the biogenesis of stalk membrane. Loss of Sdt causes strong defects in stalk membrane and rhabdomere resembling crb mutant pheno-type. Thus, proteins required for establishing the early embryonic epithelial polarity are used later for the morphogenesis of photo-receptors, with Baz and Sdt functioning in different aspects of the formation of the apical-basal cellular architecture.
机译：光感受器在果蝇form发育过程中形成，并获得精细的膜结构，包括横纹肌-腹膜和茎膜。在这里，我们表明，这些细胞结构的发展涉及两个不同的过程：需要Bazooka（Baz）的根尖基极的建立，以及需要Stardust（Sdt）的根尖膜向茎膜和横纹的区域化。在缺乏巴兹病的情况下，早期p感光细胞的顶基极极性受到损害，并且未形成可识别的顶膜结构域。相比之下，Sdt在顶基极极性中的作用更为有限，但是对于跨膜蛋白Crumbs（Crb）的正确定位必不可少，而众所周知，Smbt在茎膜的生物发生中是必需的。 Sdt的损失会在茎膜和鼠李糖单胞菌中造成严重缺陷，类似于crb突变表型。因此，建立早期胚胎上皮极性所需的蛋白质随后用于光感受器的形态发生，而Baz和Sdt在顶基细胞结构形成的不同方面起作用。

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