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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The Vibrio cholerae O139 O-antigen polysaccharide is essential for Ca~(2+)-dependent biofilm development in sea water
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The Vibrio cholerae O139 O-antigen polysaccharide is essential for Ca~(2+)-dependent biofilm development in sea water

机译：霍乱弧菌O139 O抗原多糖对海水中Ca〜（2+）依赖性生物膜的发育至关重要

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摘要

Vibrio cholerae is both an inhabitant of estuarine environments and the etiologic agent of the diarrheal disease cholera. Previous work has demonstrated that V. cholerae forms both an exopo-lysaccharide-dependent biofilm and a Ca~(2+)-dependent biofilm. In this work, we demonstrate a role for the O-antigen polysaccharide of V. cholerae in Ca~(2+)-dependent biofilm development in model and true sea water. Interestingly, V. cholerae biofilms, as well as the biofilms of several other Vibrio species, disintegrate when Ca~(2+) is removed from the bathing medium, suggesting that Ca~(2+) is interacting directly with the O-antigen polysaccharide. In the Bay of Bengal, cholera incidence has been correlated with increased sea surface height. Because of the low altitude of this region, increases in sea surface height are likely to lead to transport of sea water, marine particulates, and marine biofilms into fresh water environments. Because fresh water is Ca~(2+)-poor, our results suggest that one potential outcome of an increase is sea surface height is the dispersal of marine biofilms with an attendant increase in plank-tonic marine bacteria such as V. cholerae. Such a phenomenon may contribute to the correlation of increased sea surface height with cholera.
机译：霍乱弧菌既是河口环境的居民，也是腹泻性霍乱的病原体。先前的研究表明霍乱弧菌既形成了依赖外多糖的生物膜，又形成了依赖Ca〜（2+）的生物膜。在这项工作中，我们证明了霍乱弧菌的O抗原多糖在模型和真实海水中在Ca〜（2+）依赖性生物膜发育中的作用。有趣的是，霍乱弧菌的生物膜以及其他几个弧菌物种的生物膜在从沐浴液中去除Ca〜（2+）时会分解，这表明Ca〜（2+）直接与O-抗原多糖相互作用。在孟加拉湾，霍乱的发生与海面高度的增加有关。由于该地区的海拔低，海面高度的增加可能导致海水，海洋微粒和海洋生物膜向淡水环境的运输。因为淡水缺乏Ca〜（2+），所以我们的结果表明，增加的一个潜在结果是海面高度是海洋生物膜的散布，随之而来的是浮游性海洋细菌（如霍乱弧菌）的增加。这种现象可能有助于增加海面高度与霍乱的相关性。

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