Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

Marc Pellegrini; Gabrielle Belz; Philippe Bouillet; Andreas Strasser

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Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

机译：凋亡的Bcl-2同源性3-only蛋白Bim介导对病毒感染的急性T细胞免疫反应的关闭

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We used mutant Fas-deficient (lpr) or Bim-deficient mice to investigate the role of the death receptor and Bcl-2-regulated apoptotic pathways in terminating a physiological T cell response to herpes simplex virus infection. In WT and lpr mice CD8~+ antigen-specific T cells were deleted after viral clearance. In contrast, the immune response was not terminated in Bim-deficient mice despite viral clearance, and CD8~+ antigen-specific T cells accumulated in the spleen. Thus, Bim is dispensable for viral clearance but is necessary for the death of activated T cells when immune responses are terminated. These findings have implications for the therapeutic manipulation of immune responses to infections and immunization.

机译：我们使用突变型Fas缺陷（lpr）或Bim缺陷小鼠来研究死亡受体和Bcl-2调节的凋亡途径在终止对单纯疱疹病毒感染的生理性T细胞应答中的作用。在WT和lpr小鼠中，病毒清除后，CD8 +抗原特异性T细胞被删除。相反，尽管有病毒清除，但在Bim缺陷小鼠中免疫应答并未终止，并且CD8〜+抗原特异性T细胞在脾脏中积累。因此，Bim对于病毒清除是必不可少的，但在免疫反应终止时对于活化的T细胞的死亡是必不可少的。这些发现对对感染和免疫的免疫反应的治疗性操作具有影响。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2003年第24期|p.14175-14180|共6页
作者
Marc Pellegrini; Gabrielle Belz; Philippe Bouillet; Andreas Strasser;
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作者单位

Divisions of Molecular Genetics of Cancer The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. The Proapoptotic BCL-2 Homology Domain 3-Only Protein Bim Is Not Critical for Acute Excitotoxic Cell Death [J] . Panos Theofilas Peter Bedner Kerstin Hüttmann Martin Theis Christian Steinhäuser Stephan Frank Journal of Neuropathology and Experimental Neurology . 2009,第1期

机译：促凋亡的BCL-2同源域3仅蛋白质Bim对于急性兴奋性细胞死亡并不重要
2. The proapoptotic BCL-2 homology domain 3-only protein Bim is not critical for acute excitotoxic cell death. [J] . Theofilas P, Bedner P, Huttmann K, Journal of Neuropathology and Experimental Neurology: Official Journal of the American Association of Neuropathologists, Inc . 2009,第1期

机译：促凋亡的BCL-2同源域3蛋白Bim对急性兴奋性毒性细胞死亡并不重要。
3. Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. [J] . Liu Z, Lu H, Jiang Z, Molecular cancer research: MCR . 2005,第1期

机译：载脂蛋白16，一种新型的凋亡前Bcl-2同源性3蛋白，在癌细胞中诱导线粒体介导的凋亡。
4. Apoptosis Induced in Ovarian Cancer Cells by HPMA Copolymer-Bound DoxorubicinIs Mediated by Bcl-2 Family Proteins [C] . Alexander Malugin, Pavla Kopecková, Jindrich Kopecek Annual meeting exposition of the Controlled Release Society . 2005

机译：Bcl-2家族蛋白介导的HPMA共聚物结合的阿霉素诱导卵巢癌细胞凋亡。
5. Type I Interferons Negatively Regulate Foxp3+ Regulatory T Cells during Acute Viral Infection and Autoimmunity [D] . Srivastava, Shivani 2014

机译：I型干扰素在急性病毒感染和自身免疫过程中负调控Foxp3 +调节性T细胞。
6. Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim [O] . Marc Pellegrini, Gabrielle Belz, Philippe Bouillet, 2003

机译：凋亡的Bcl-2同源性3-only蛋白Bim介导对病毒感染的急性T细胞免疫反应的关闭
7. Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim [O] . Pellegrini, Marc, Belz, Gabrielle, Bouillet, Philippe, 2003

机译：凋亡的Bcl-2同源性3-only蛋白Bim介导对病毒感染的急性T细胞免疫反应的关闭

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

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