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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: Implications for HIV-1 vaccine development
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Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: Implications for HIV-1 vaccine development

机译：SHIV感染后6小时而非24小时将中和IgG转移至猕猴可提供灭菌保护：对HIV-1疫苗开发的影响

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摘要

Passive transfer of high-titered antiviral neutralizing IgG, known to confer sterilizing immunity in pig-tailed monkeys, has been used to determine how soon after virus exposure neutralizing antibodies (NAbs) must be present to block a simian immunodeficiency virus (SIV)/HIV chimeric virus infection. Sterilizing protection was achieved in three of four macaques receiving neutralizing IgG 6 h after intravenous SIV/HIV chimeric virus inoculation as monitored by PCR analyses of and attempted virus isolations from plasma, peripheral blood mononuclear cell, and lymph node specimens. In the fourth animal, the production of progeny virus was suppressed for >4 weeks. A delay in transferring NAbs until 24 h after virus challenge resulted in infection in two of two monkeys. These results suggest that even if a vaccine capable of eliciting broadly reactive NAbs against primary HIV-1 were at hand, the Abs generated must remain at, or rapidly achieve, high levels within a relatively short period after exposure to virus to prevent the establishment of a primate lentivirus infection.
机译：高滴度抗病毒中和IgG的被动转移，已知可在猪尾猴中提供杀菌免疫，已被用来确定必须在多长时间后出现中和抗体（NAbs）以阻断猿猴免疫缺陷病毒（SIV）/ HIV嵌合病毒感染。静脉注射SIV / HIV嵌合病毒后6小时，接受中和IgG的四只猕猴中有三只获得了灭菌保护，这是通过对血浆，外周血单核细胞和淋巴结标本进行PCR分析并从中分离病毒来进行监测的。在第四只动物中，后代病毒的产生被抑制了> 4周。将NAbs转移延迟至病毒攻击后24小时，导致两只猴子中的两只被感染。这些结果表明，即使手头有一种能够引起针对原发性HIV-1的广泛反应性NAb的疫苗，所产生的Abs也必须在暴露于病毒后的相对短时间内保持或迅速达到高水平，以防止建立Abs。灵长类慢病毒感染。

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