...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The population structure of Mycobacterium bovis in Great Britain: Clonal expansion
【24h】

The population structure of Mycobacterium bovis in Great Britain: Clonal expansion

机译：英国牛分枝杆菌的种群结构：克隆扩增

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have analyzed 11,500 isolates of Mycobacterium bovis (the cause of tuberculosis in cattle and other mammals) isolated in Great Britain (England, Wales and Scotland)] and characterized by spoligotype. Genetic exchange between cells is rare or absent in strains of the Mycobacterium tuberculosis complex so that, by using spoligotypes, it is possible to recognize "clones" with a recent common ancestor. The distribution of variable numbers of tandem repeats types in the most common clone in the data set is incompatible with random mutation and drift. The most plausible explanation is a series of "clonal expansions," and this interpretation is supported by the geographical distribution of different genotypes. We suggest that the clonal expansion of a genotype is caused either by the spread of a favorable mutation, together with all other genes present in the ancestral cell in which the mutation occurred, or by the invasion of a novel geographical region by a limited number of genotypes. A similar pattern is observed in M. tuberculosis (the main cause of tuberculosis in humans). The significance of clonal expansion in other bacteria that have recombination is discussed.
机译：我们分析了在英国（英格兰，威尔士和苏格兰）分离的11,500株牛分枝杆菌（牛和其他哺乳动物的结核病病原体）分离株，并以spoligotype为特征。在结核分枝杆菌复合体的菌株中，细胞之间的遗传交换很少或不存在，因此，通过使用spoligotypes，可以识别具有最近共同祖先的“克隆”。在数据集中最常见的克隆中，可变数目的串联重复序列类型的分布与随机突变和漂移不兼容。最合理的解释是一系列“克隆扩展”，并且该解释得到不同基因型的地理分布的支持。我们建议，基因型的克隆性扩张是由有利突变的扩散，以及发生突变的祖先细胞中存在的所有其他基因，或由新地理区域的有限数量入侵引起的。基因型。在结核分枝杆菌（人类结核病的主要原因）中观察到了类似的模式。讨论了在具有重组的其他细菌中克隆扩增的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号