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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
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Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

机译：正常和白血病的造血功能：白血病是干细胞疾病还是干细胞特征的重新获得？

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摘要

Leukemia can be viewed as a newly formed, abnormal hemato-poietic tissue initiated by a few leukemic stem cells (LSCs) that undergo an aberrant and poorly regulated process of organogen-esis analogous to that of normal hematopoietic stem cells. A hallmark of all cancers is the capacity for unlimited self-renewal, which is also a defining characteristic of normal stem cells. Given this shared attribute, it has been proposed that leukemias may be initiated by transforming events that take place in hematopoietic stem cells. Alternatively, leukemias may also arise from more committed progenitors caused by mutations and/or selective expression of genes that enhance their otherwise limited self-renewal capabilities. Identifying the LSCs for each type of leukemia is a current challenge and a critical step in understanding their respective biologies and may provide key insights into more effective treatments. Moreover, LSC identification and purification will provide a powerful diagnostic, prognostic, and therapeutic tool in the clinic.
机译：白血病可以看作是一种新形成的异常造血组织，由少数白血病干细胞（LSC）引发，该组织经历异常的，调控不良的器官发生过程，类似于正常的造血干细胞。所有癌症的标志是无限的自我更新能力，这也是正常干细胞的定义特征。考虑到这种共有的属性，已经提出可以通过转化造血干细胞中发生的事件来引发白血病。或者，白血病也可能是由基因突变和/或选择性表达所引起的更定型的祖细胞引起的，这些基因增强了它们原本有限的自我更新能力。识别每种类型的白血病的LSC是当前的挑战，也是理解其各自生物学的关键步骤，并且可能为更有效的治疗方法提供关键见解。此外，LSC的鉴定和纯化将为临床提供强大的诊断，预后和治疗工具。

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