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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Activation of Notch signaling pathway precedes heart regeneration in zebrafish
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Activation of Notch signaling pathway precedes heart regeneration in zebrafish

机译：Notch信号通路的激活先于斑马鱼的心脏再生

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摘要

Several vertebrates display the ability to regenerate parts of their body after amputation. During this process, differentiated cells reenter the cell cycle and proliferate to generate a mass of undif-ferentiated cells. Repatterning mechanisms act on these cells to eventually shape a regenerated tissue or organ that replaces the amputated one. Experiments with regenerating limbs/fins in newts and zebrafish have shown that members of the Msx family of homeodomain-containing transcription factors play key roles during blastema formation and patterning. Here we show that adult zebrafish have a remarkable capacity to regenerate the heart in a process that involves up-regulation of msxB and msxC genes. We present evidence indicating that heart regeneration involves the execution of a specific genetic program, rather than redeployment of a cardiac development program. Preceding Msx activation, there is a marked increase in the expression of notch1b and deltaC, which we show are also up-regulated during fin regeneration. These data suggest a role for the Notch pathway in the activation of the regenerative response. Taken together, our results underscore the use of zebrafish as a model for investigating the process of regeneration in particular and the biology of stem cells in general. Advances in these fields will undoubtedly aid in the implementation of strategies for regenerative medicine.
机译：截肢后，一些脊椎动物表现出能够再生其身体局部的能力。在此过程中，分化的细胞重新进入细胞周期并增殖以产生大量未分化的细胞。再散射机制作用于这些细胞上，最终形成再生的组织或器官，代替被截肢的组织或器官。在new和斑马鱼中再生肢体/鳍的实验表明，含Homeodomain的转录因子Msx家族的成员在胚泡形成和模式形成过程中起关键作用。在这里，我们显示成年斑马鱼在涉及msxB和msxC基因上调的过程中具有显着的再生心脏能力。我们提供的证据表明，心脏再生涉及特定基因程序的执行，而不是心脏发育程序的重新部署。在Msx激活之前，notch1b和deltaC的表达显着增加，我们显示这些在鳍再生期间也被上调。这些数据表明Notch途径在再生应答的激活中的作用。综上所述，我们的结果强调了使用斑马鱼作为模型，特别是研究再生过程以及一般而言干细胞的生物学模型。这些领域的进展无疑将有助于实施再生医学战略。

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