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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Nuclear reprogramming and stem cell creation
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Nuclear reprogramming and stem cell creation

机译：核重编程和干细胞创建

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摘要

The transplantation of a somatic cell nucleus to an enucleated egg results in a major reprogramming of gene expression and switch in cell fate. We review the efficiency of nuclear reprogramming by nuclear transfer. The serial transplantation of nuclei from defective first-transfer embryos and the grafting of cells from such embryos to normal host embryos greatly increases the proportion of nuclei that can be seen to have been reprogrammed. We discuss possible reasons for the early failure of most nuclear transfers from differentiated cells and describe the potential value of growing oocytes, rather than unfertilized eggs, as a source of nuclear reprogramming molecules and for the eventual identification of these molecules. Nuclear transfer provides a possible route for the creation of stem cells from adult somatic cells.
机译：体细胞核向去核卵的移植导致基因表达的重大重编程和细胞命运的转变。我们回顾了通过核转让进行核重新规划的效率。从有缺陷的初次转移胚胎中进行核的连续移植，以及将细胞从此类胚胎移植到正常宿主胚胎中，大大增加了可以重新编程的核比例。我们讨论了分化细胞中大多数核转移早期失败的可能原因，并描述了正在生长的卵母细胞而不是未受精卵的潜在价值，它是核重编程分子的来源并最终鉴定了这些分子。核转移为从成年体细胞创建干细胞提供了可能的途径。

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