...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Pheromone-mediated gene expression in the honey bee brain
【24h】

Pheromone-mediated gene expression in the honey bee brain

机译：信息素介导的蜜蜂脑中基因表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We tested the hypothesis that queen mandibular pheromone (QMP) causes changes in gene expression in the brain of the adult worker honey bee, and that these changes can be correlated to the downstream behavioral responses induced by QMP. In support of the first hypothesis, cage experiments revealed that QMP transiently regulated expression of several hundred genes and chronically regulated the expression of 19 genes. Several of these genes were also affected by QMP in experiments with bee colonies in the field, demonstrating robust gene regulation by pheromone. To evaluate the second hypothesis, we focused on one function of QMP: delaying the transition from working in the hive (e.g., brood care, or "nursing") to foraging. We compared the list of QMP-regulated genes with the lists of genes differentially regulated in nurse and forager brains generated in a separate study. QMP consistently activated "nursing genes" and repressed "foraging genes," suggesting that QMP may delay behavioral maturation by regulating genes in the brain that produce these behavioral states. We also report here on an ortholog of the Drosophila transcription factor kruppel homolog 1 that was strongly regulated by QMP, especially in the mushroom bodies of the bee brain. These results demonstrate chronic gene regulation by a primer pheromone and illustrate the potential of genomics to trace the actions of a pheromone from perception to action, and thereby provide insights into how pheromones regulate social life.
机译：我们测试了下颌后信息素（QMP）导致成年工蜂的大脑中基因表达发生变化的假说，并且这些变化可能与QMP诱导的下游行为反应有关。为了支持第一个假设，笼实验显示，QMP瞬时调节数百个基因的表达，并长期调节19个基因的表达。在野外蜂群实验中，这些基因中的几个也受到QMP的影响，证明了信息素对基因的调控很强。为了评估第二个假设，我们将重点放在QMP的功能上：延迟从在蜂巢中工作（例如，育雏或“护理”）到觅食的过渡。我们将QMP调节的基因列表与在另一项研究中生成的护士和觅食者大脑中差异调节的基因列表进行了比较。 QMP持续激活“护理基因”并抑制“觅食基因”，这表明QMP可能通过调节大脑中产生这些行为状态的基因来延迟行为成熟。我们还在这里报道了果蝇转录因子kruppel同源物1的直系同源物，该直系同源物受到QMP的强烈调节，尤其是在蜜蜂大脑的蘑菇体内。这些结果证明了引物信息素对基因的长期调控，并说明了基因组学从信息知觉到行动追踪信息素的作用的潜力，从而提供了信息素如何调节社会生活的见识。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号