Activated glycogen synthase-3βsuppresses cardiac hypertrophy in vivo

Christopher L. Antos; Timothy A. McKinsey; Norbert Frey

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Activated glycogen synthase-3βsuppresses cardiac hypertrophy in vivo

机译：活化糖原合酶-3β抑制体内心肌肥大

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The adult myocardium responds to a variety of pathologic stimuli by hypertrophic growth that frequently progresses to heart failure. The calcium/calmodulin-dependent protein phosphatase cal- cineurin is a potent transducer of hypertrophic stimuli. Calcineurin dephosphorylates members of the nuclear factor of activated T cell (NFAT) family of transcription factors, which results in their trans- location to the nucleus and activation of calcium-dependent genes. Glycogen synthase kinase-3 (GSK-3) phosphorylates NFAT proteins and antagonizes the actions of calcineurin by stimulating NFAT nuclear export.

机译：成年心肌通过肥大性生长对多种病理刺激作出反应，肥大性生长经常发展为心力衰竭。钙/钙调蛋白依赖性蛋白磷酸酶钙调神经磷酸酶是肥大刺激的有效转导者。钙调神经磷酸酶使转录因子激活的T细胞（NFAT）家族的核因子成员脱磷酸化，这导致它们转位至细胞核并激活钙依赖性基因。糖原合酶激酶3（GSK-3）磷酸化NFAT蛋白，并通过刺激NFAT核输出来拮抗钙调神经磷酸酶的作用。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第2期|p.907-912|共6页
作者
Christopher L. Antos; Timothy A. McKinsey; Norbert Frey;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Activation of peroxisome proliferator-activated receptor-alpha prevents glycogen synthase 3beta phosphorylation and inhibits cardiac hypertrophy. [J] . Li R, Zheng W, Pi R, FEBS letters. . 2007,第17期

机译：过氧化物酶体增殖物激活受体-α的激活可防止糖原合酶3β磷酸化并抑制心脏肥大。
2. Cardiac-Specific Activation of Angiotensin II Type 1 Receptor–Associated Protein Completely Suppresses Cardiac Hypertrophy in Chronic Angiotensin II–Infused Mice [J] . Hiromichi Wakui, Kouichi Tamura, Yutaka Tanaka, Hypertension: An Official Journal of the American Heart Association . 2010,第5期

机译：特定于心脏的血管紧张素II 1型受体相关蛋白的激活完全抑制了慢性血管紧张素II注入小鼠的心脏肥大。
3. Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling [J] . ZhangM., TakimotoE., LeeD.-I., Circulation: An Official Journal of the American Heart Association . 2012,第8期

机译：病理性心肌肥大改变了5型磷酸二酯酶的细胞内靶向从一氧化氮合酶3到利钠肽信号传导
4. Cardiac activation mapping in a transgenic mouse model of cardiac hypertrophy [C] . OLeary, E.A., Maass-Moreno, . 1998

机译：心脏肥大的转基因小鼠模型中的心脏激活作图
5. In vivo MRI of mouse heart at 11.7 T: Monitoring of stem-cell therapy for myocardial infarction and evaluation of cardiac hypertrophy. [D] . Kulkarni, Aditi C. 2008

机译：小鼠心脏在11.7 T时的体内MRI：监测用于心肌梗塞的干细胞疗法和评估心肌肥大。
6. Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo [O] . Christopher L. Antos, Timothy A. McKinsey, Norbert Frey, 2002

机译：活化的糖原合酶3β抑制体内心肌肥大
7. Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo [O] . Antos, Christopher L., McKinsey, Timothy A., Frey, Norbert, 2002

机译：活化的糖原合酶3β抑制体内心肌肥大

Activated glycogen synthase-3βsuppresses cardiac hypertrophy in vivo

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