The iscS gene is essential for the biosynthesis of 2-selenouridine in tRNA and the selenocysteine- containing formate dehydrogenase H

Hisaaki Mihara; Shin-ichiro Kato; Gerard M. Lacourciere

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The iscS gene is essential for the biosynthesis of 2-selenouridine in tRNA and the selenocysteine- containing formate dehydrogenase H

机译：iscS基因对于tRNA和含硒代半胱氨酸的甲酸脱氢酶H的2-硒代尿苷的生物合成至关重要

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Three NifS-like proteins, IscS, CSD, and CsdB, from Escherichia coli catalyze the removal of sulfur and selenium from L-cysteine and L-selenocysteine, respectively, to form L-alanine. These enzymes are proposed to function as sulfur-delivery proteins for iron-sulfur cluster, thiamin, 4-thiouridine, biotin, and molybdopterin. Re- cently, it was reported that selenium mobilized from free seleno- cysteine is incorporated specifically into a selenoprotein and tRNA in vivo, supporting the involvement of the NifS-like proteins in selenium metabolism.

机译：来自大肠杆菌的三种NifS样蛋白IscS，CSD和CsdB分别催化从L-半胱氨酸和L-硒代半胱氨酸中去除硫和硒，形成L-丙氨酸。这些酶被提议作为铁-硫簇，硫胺素，4-硫尿苷，生物素和钼蝶呤的硫传递蛋白。最近，有报道说，从游离硒代半胱氨酸中提取的硒在体内被特异地掺入硒蛋白和tRNA中，从而支持NifS样蛋白参与硒的代谢。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第10期|p.6679-6683|共5页
作者
Hisaaki Mihara; Shin-ichiro Kato; Gerard M. Lacourciere;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. The iscS gene is essential for the biosynthesis of 2-selenouridine in tRNA and the selenocysteine-containing formate dehydrogenase H [J] . Hisaaki Mihara, Shin-ichiro Kato, Gerard M. Lacourciere, Proceedings of the National Academy of Sciences of the United States of America . 2002,第10期

机译：iscS基因对于tRNA和含硒代半胱氨酸的甲酸脱氢酶H的2-硒代尿苷的生物合成至关重要
2. Class I and II aminoacyl‐tRNA synthetase tRNA groove discrimination created the first synthetase–tRNA cognate pairs and was therefore essential to the origin of genetic coding [J] . Carter Charles W., Wills Peter R. IUBMB life . 2019,第8期

机译：I类和II类氨基酰基-TRNA合成酶TRNA沟槽辨别产生了第一合成酶-TRNA同源对，因此对遗传编码的来源是必不可少的
3. Site-directed mutagenesis of the essential arginine of the formate dehydrogenase active centre [J] . Andrey G. Galkin, Alexey S. Kutsenko, Nataliya P. Bajulina, Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology . 2002,第1期

机译：甲酸脱氢酶活性中心精氨酸的定点诱变
4. Construction of L-tert-Leucine Producing Strain by Expressing Heterologous Leucine Dehydrogenase and Formate Dehydrogenase in Escherichia coli [C] . Junzhen Bai, Yajian Song, Xuegang Luo, International conference on applied biotechnology . 2015

机译：在大肠杆菌中表达异源亮氨酸脱氢酶和甲酰胺脱氢酶构建L-叔亮氨酸生产菌株
5. Conversion of Carbon Dioxide to Formate by a Formate Dehydrogenase from Cupriavidus necator [D] . Yu, Xuejun. 2018

机译：二氧化碳转化为Cupriavidus Necator的甲酸脱氢酶培养
6. The iscS gene is essential for the biosynthesis of 2-selenouridine in tRNA and the selenocysteine-containing formate dehydrogenase H [O] . Hisaaki Mihara, Shin-ichiro Kato, Gerard M. Lacourciere, 2002

机译：iscS基因对于tRNA和含硒代半胱氨酸的甲酸脱氢酶H的2-硒代尿苷的生物合成至关重要
7. The iscS gene is essential for the biosynthesis of 2-selenouridine in tRNA and the selenocysteine-containing formate dehydrogenase H [O] . Mihara, Hisaaki, Kato, Shin-ichiro, Lacourciere, Gerard M., 2002

机译：iscS基因对于tRNA和含硒代半胱氨酸的甲酸脱氢酶H的2-硒代尿苷的生物合成至关重要
8. Amino Acid Sequence Analysis of Escherichia coli Formate Dehydrogenase (FDHH)Confirms that TGA in the Gene Encodes Selenocysteine in the Gene Product [R] . Stadtman, T. C., Davis, J. N., Ching, W. M., 1991

机译：大肠杆菌甲酸脱氢酶（FDHH）的氨基酸序列分析证实基因中的TGa基因产物中的硒代半胱氨酸

The iscS gene is essential for the biosynthesis of 2-selenouridine in tRNA and the selenocysteine- containing formate dehydrogenase H

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