Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: Properties of fast and slow gating mechanisms

Feliksas F. Bukauskas; Angele Bukauskiene; Vytas K. Verselis

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Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: Properties of fast and slow gating mechanisms

机译：异型连接蛋白45 /连接蛋白43-EGFP间隙连接的耦合不对称：快速和慢速门控机制的性质

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Although fast and slow gating mechanisms have been described in gap junctions (GJs), their relative contributions to dependence on transjunctional voltage, Vj, is still unclear. We used cell lines expressing wild-type connexin 45 (Cx45) and connexin 43 fused with enhanced green fluorescent protein (Cx43-EGFP) to examine mechanisms of gating in homo- and heterotypic GJs formed of these connexins. Macroscopically Cx45/Cx45 channels show high sensitivity to Vj. Cx45 channels demonstrate two types of gating: fast transitions between open and residual states and slow tran- sitions between open and completely closed states.

机译：尽管已经在间隙结（GJ）中描述了快速和慢速门控机制，但是它们对依赖跨结电压Vj的相对贡献仍然不清楚。我们使用表达野生型连接蛋白45（Cx45）和连接蛋白43与增强的绿色荧光蛋白（Cx43-EGFP）融合的细胞系来检查由这些连接蛋白形成的同型和异型GJ中的门控机制。宏观上，Cx45 / Cx45通道显示出对Vj的高灵敏度。 Cx45通道演示了两种门控类型：打开状态和残余状态之间的快速转换以及打开状态和完全关闭状态之间的缓慢转换。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第10期|p.7113-7118|共6页
作者
Feliksas F. Bukauskas; Angele Bukauskiene; Vytas K. Verselis;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: Properties of fast and slow gating mechanisms [J] . Feliksas F. Bukauskas, A. Bukauskiene Angele, Vytas K. Verselis, Proceedings of the National Academy of Sciences of the United States of America . 2002,第10期

机译：异型连接蛋白45 /连接蛋白43-EGFP间隙连接的耦合不对称：快速和慢速门控机制的性质
2. Gating properties of heterotypic gap junction channels formed of connexins 40, 43, 45 [J] . Rackauskas M, Kreuzberg MM, Pranevicius M, Biophysical Journal . 2007,第6期

机译：由连接蛋白40、43、45形成的异型间隙连接通道的门控特性
3. Mono-Heteromeric Configurations of Gap Junction Channels Formed by Connexin43 and Connexin45 Reduce Unitary Conductance and Determine both Voltage Gating and Metabolic Flux Asymmetry [J] . Guoqiang Zhong, Nazem Akoum, Daniel A. Appadurai, Frontiers in Physiology . 2017,第12期

机译：通过Connexin43和Connexin45形成的间隙结通道的单型异位配置减少了单一的电导，并确定电压门控和代谢助焊剂不对称性
4. Identification of phosphorylation sites in the myocardial gap junction protein connexin45 [C] . Richard Y-C. Huang, Evelyn M. Kanter, Henry W. Rohrs, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：心肌间隙结蛋白Connexin45中磷酸化位点的鉴定
5. Selectivity of connexin43 and connexin40 comprised gap junctions. [D] . Heyman, Nathanael. 2007

机译：连接蛋白43和连接蛋白40的选择性包括间隙连接。
6. Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: Properties of fast and slow gating mechanisms [O] . Feliksas F. Bukauskas, Angele Bukauskiene, Vytas K. Verselis, 2002

机译：异型连接蛋白45 /连接蛋白43-EGFP间隙连接的耦合不对称：快速和慢速门控机制的性质
7. Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: Properties of fast and slow gating mechanisms [O] . Bukauskas, Feliksas F., Bukauskiene, Angele, Verselis, Vytas K., 2002

机译：异型连接蛋白45 /连接蛋白43-EGFP间隙连接的耦合不对称：快速和慢速门控机制的性质

Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: Properties of fast and slow gating mechanisms

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