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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: Cell fate is regulated at the level of gene expression
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Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: Cell fate is regulated at the level of gene expression

机译：人类多形核白细胞在受体介导的吞噬过程中基因表达的总体变化：细胞命运受基因表达水平的调节

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摘要

Phagocytes are a critical component of the innate immune re- sponse in humans and eliminate invading microorganisms through a process known as phagocytosis. Two distinct receptor-linked phagocytic pathways, one with Ab receptors (FcRs; FcR, Fc recep- tor) and the other complement receptors (CRs), mediate binding and ingestion of pathogens by human polymorphonuclear leuko- cytes (PMNs). Although progress has been made toward defining complex signal transduction processes that underlie phagocytosis in each pathway, very little is known about gene regulation during or after phagocytosis.
机译：吞噬细胞是人类先天免疫反应的关键组成部分，它通过吞噬作用消除入侵的微生物。两种不同的受体相关吞噬途径，一种具有Ab受体（FcR； FcR，Fc受体），另一种具有补体受体（CR），可通过人多形核白细胞（PMN）介导病原体的结合和摄入。尽管在定义每个吞噬作用基础的复杂信号转导过程方面已取得进展，但对吞噬过程中或之后的基因调控了解甚少。

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