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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Identification of a protein secretory pathway for the secretion of heat-labile enterotoxin by an enterotoxigenic strain of Escherichia coli
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Identification of a protein secretory pathway for the secretion of heat-labile enterotoxin by an enterotoxigenic strain of Escherichia coli

机译：鉴定肠毒素的大肠杆菌分泌热不稳定肠毒素的蛋白质分泌途径

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摘要

Enterotoxigenic Escherichia coli (ETEC) is an enteric pathogen that causes cholera-like diarrhea in humans and animals. ETEC secretes a heat-labile enterotoxin (LT), which resembles cholera toxin, but the actual mechanism of LT secretion is presently unknown. We have identified a previously unrecognized type II protein secretion pathway in the prototypic human ETEC strain, H10407 (serotype O78:H11). The genes for this pathway are absent from E. coli K-12, although examination of the K-12 genome suggests that it prob- ably once possessed them. The secretory pathway bears significant homology at the amino acid level to the type II protein secretory pathway required by Vibrio cholerae for the secretion of cholera toxin.
机译：产肠毒素的大肠杆菌（ETEC）是一种肠道病原体，可在人和动物中引起霍乱样腹泻。 ETEC分泌类似于霍乱毒素的不耐热肠毒素（LT），但目前尚不清楚LT分泌的实际机制。我们已经在原型人类ETEC菌株H10407（血清型O78：H11）中鉴定了一个以前无法识别的II型蛋白质分泌途径。大肠杆菌K-12中没有该途径的基因，尽管对K-12基因组的检查表明它很可能曾经拥有它们。该分泌途径在氨基酸水平上与霍乱弧菌分泌霍乱毒素所需的II型蛋白质分泌途径具有显着同源性。

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