Interaction of Gα_12 with Gα_13 and Gα_q signaling pathways

Jennifer L. Gu; Stefan Muller; Valeria Mancino

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Interaction of Gα_12 with Gα_13 and Gα_q signaling pathways

机译：Gα_12与Gα_13和Gα_q信号通路的相互作用

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摘要

The G_12 subfamily of heterotrimeric G-proteins consists of two members, G_12 and G_13. Gene-targeting studies have revealed a role for G_13 in blood vessel development. Mice lacking the α subunit of G_13 die around embryonic day 10 as the result of an angiogenic defect. On the other hand, the physiological role of G_12 is still unclear. To address this issue, we generated Gα12-deficient mice. In contrast to the Gα_13-deficient mice, Gα_12-deficient mice are viable, fertile, and do not show apparent abnormalities. However, Gα_12 does not seem to be entirely redundant, because in the offspring generated from Gα_12 ± Gα13 ± intercrosses, at least one intact Gα_12 allele is required for the survival of animals with only one Gα_13 allele.

机译：异三聚体G蛋白的G_12亚家族由两个成员G_12和G_13组成。基因靶向研究已经揭示了G_13在血管发育中的作用。缺乏G_13α亚基的小鼠在胚胎第10天左右死于血管生成缺陷。另一方面，G_12的生理作用仍不清楚。为了解决这个问题，我们产生了Gα12缺陷型小鼠。与缺乏Gα_13的小鼠相反，缺乏Gα_12的小鼠是活的，可育的，并且没有表现出明显的异常。但是，Gα_12似乎并不是完全多余的，因为在由Gα_12±Gα13±杂交产生的后代中，至少有一个完整的Gα_12等位基因对于只有一个Gα_13等位基因的动物生存是必需的。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第14期|p.9352-9357|共6页
作者
Jennifer L. Gu; Stefan Muller; Valeria Mancino;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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机译：G alpha（12）与G alpha（13）和G alpha（q）信号通路的相互作用

Interaction of Gα_12 with Gα_13 and Gα_q signaling pathways

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