Crystal structure of monomeric human β-2-microglobulin reveals clues to its amyloidogenic properties

Chi H. Trinh; David P. Smith; Arnout P. Kalverda

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Crystal structure of monomeric human β-2-microglobulin reveals clues to its amyloidogenic properties

机译：单体人β-2-微球蛋白的晶体结构揭示了其淀粉样蛋白生成特性的线索

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Dissociation of human β-2-microglobulin (β_2m) from the heavy chain of the class I HLA complex is a critical first step in the formation of amyloid fibrils from this protein. As a consequence of renal failure, the concentration of circulating monomeric β_2m increases, ultimately leading to deposition of the protein into amyloid fibrils and development of the disorder, dialysis-related amyloidosis. Here we present the crystal structure of a monomeric form of human β_2m determined at 1.8-A resolution that reveals remarkable structural changes relative to the HLA-bound protein.

机译：将人β-2-微球蛋白（β_2m）从I类HLA复合物的重链上解离是从该蛋白形成淀粉样蛋白原纤维的关键第一步。肾衰竭的结果是，循环性单体β_2m的浓度增加，最终导致蛋白质沉积到淀粉样蛋白原纤维中，并发展为与透析有关的淀粉样变性病。在这里，我们介绍了以1.8-A分辨率测定的人β_2m单体形式的晶体结构，该结构揭示了相对于HLA结合蛋白的显着结构变化。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第15期|p.9771-9776|共6页
作者
Chi H. Trinh; David P. Smith; Arnout P. Kalverda;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets [J] . Soriaga Angela B., Sangwan Smriti, Macdonald Ramsay, The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2016,第26期

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2. The solution structures of native and patient monomeric human IgA1 reveal asymmetric extended structures: implications for function and IgAN disease [J] . The Biochemical Journal . 2015,第Pta2期

机译：天然和患者单体人IgA1的溶液结构揭示了不对称的延伸结构：对功能和IgAn病的影响
3. The solution structures of native and patient monomeric human IgA1 reveal asymmetric extended structures: implications for function and IgAN disease [J] . Gar?Kay Hui, David?W. Wright, Owen?L. Vennard, The biochemical journal . 2015,第2期

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4. Polarization structure of biospeckle fields in crosslinked tissues of a human organism: 2. Crystal optic properties of the transverse and longitudinal sections of the bone [C] . V.P. Pishak, Chernivtsy Medical Academy, Chernivtsy, International conference on correlation optics . 1998

机译：人体交联组织中生物斑点场的极化结构：2.骨的横向和纵向截面的晶体光学特性
5. The crystal structure of the major coat protein of the bacteriophage PRD1 reveals an evolutionary link with human adenovirus [D] . Benson, Stacy Douglas 1999

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6. Crystal structure of monomeric human β-2-microglobulin reveals clues to its amyloidogenic properties [O] . Chi H. Trinh, David P. Smith, Arnout P. Kalverda, 2002

机译：单体人β-2-微球蛋白的晶体结构揭示了其淀粉样蛋白生成特性的线索
7. Crystal structure of monomeric human β-2-microglobulin reveals clues to its amyloidogenic properties [O] . Trinh, Chi H., Smith, David P., Kalverda, Arnout P., 2002

机译：单体人β-2-微球蛋白的晶体结构揭示了其淀粉样蛋白生成特性的线索

Crystal structure of monomeric human β-2-microglobulin reveals clues to its amyloidogenic properties

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