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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >VEGF increases engraftment of bone marrow-derived endothelial progenitor cells (EPCs) into vasculature of newborn murine recipients
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VEGF increases engraftment of bone marrow-derived endothelial progenitor cells (EPCs) into vasculature of newborn murine recipients

机译：VEGF增加了骨髓来源的内皮祖细胞（EPC）植入新生鼠受体血管系统的能力

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Recent evidence suggests that bone marrow-derived angioblasts or endothelial progenitor cells circulate in peripheral blood and can incorporate at sites of pathologic neovascularization or during the ovarian cycle. However, the incorporation of endothelial progenitor cells into vessels of nonischemic tissues in adult animals has not been observed. We hypothesized that the vascular microenviron-ment differs between newborn and adult animals, and that donor endothelial cell progenitors would engraft in rapidly growing normal tissues during the neonatal period. After nonablative administration of bone marrow cells either at birth or at 4 weeks of age, donor-derived endothelial cells were found only in the neovasculature of the newborn recipients. Both the incorporation of donor endothelial cells into the newborn neovasculature as well as tissue vascularity were significantly increased by coadminister-ing vascular endothelial growth factor with bone marrow cells. These findings suggest that bone marrow-derived endothelial progenitor cells can contribute to neovascularization during the newborn period and are responsive to vascular endothelial growth factor.
机译：最近的证据表明，骨髓来源的成血管细胞或内皮祖细胞在外周血中循环，并可以在病理性新血管形成部位或卵巢周期中整合。但是，尚未观察到内皮祖细胞掺入成年动物的非缺血性组织的血管中。我们假设新生和成年动物的血管微环境不同，并且在新生儿期供体内皮细胞祖细胞将植入快速生长的正常组织中。在出生时或4周龄非消融性给予骨髓细胞后，仅在新生受体的新脉管系统中发现了供体来源的内皮细胞。通过将血管内皮生长因子与骨髓细胞并用，可将供体内皮细胞并入新生儿新脉管系统以及组织血管均显着增加。这些发现表明，骨髓来源的内皮祖细胞可在新生儿期促进新血管形成，并对血管内皮生长因子有反应。

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