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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Circadian genes in a blind subterranean mammal II: Conservation and uniqueness of the three Period homologs in the blind subterranean mole rat, Spalax ehrenbergi superspecies
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Circadian genes in a blind subterranean mammal II: Conservation and uniqueness of the three Period homologs in the blind subterranean mole rat, Spalax ehrenbergi superspecies

机译：隐性地下哺乳动物的昼夜节律基因II：隐性地下mole鼠，Spalax ehrenbergi超级物种的三个时期同系物的保存和独特性

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摘要

We demonstrated that a subterranean, visually blind mammal has a functional set of three Per genes that are important components of the circadian clockwork in mammals. The mole rat superspecies Spalax ehrenbergi is a blind subterranean animal that lives its entire life underground in darkness. It has degenerated eyes, but the retina and highly hypertrophic harderian gland are involved in photoperi-odic perception. All three Per genes oscillate with a periodicity of 24 h in the suprachiasmatic nuclei, eye, and harderian gland and are expressed in peripheral organs. This oscillation is maintained under constant conditions. The light inducibility of sPer1 and sPer2, which are similar in structure to those of other mammals, indicates the role of these genes in clock resetting. However, sPer3 is unique in mammals and has two truncated isoforms, and its expressional analysis leaves its function unresolved. Per's expression analysis in the harderian gland suggests an important participation of this organ in the stabilization and resetting mechanism of the central pacemaker in the suprachiasmatic nuclei and in unique adaptation to life underground.
机译：我们证明了，一个地下的，视觉上失明的哺乳动物具有三个Per基因的功能集，这是哺乳动物昼夜发条的重要组成部分。 rat鼠超种Spalax ehrenbergi是一种盲的地下动物，一生都在黑暗中生活。它具有退化的眼睛，但视网膜和高度肥大的哈德氏腺体参与光周期感觉。这三个Per基因全部在视交叉上核，眼和哈德氏腺中振荡，周期为24小时，并在外周器官中表达。该振荡在恒定条件下保持。 sPer1和sPer2的光诱导性与其他哺乳动物在结构上相似，表明这些基因在时钟重置中的作用。但是，sPer3在哺乳动物中是独特的，具有两个截短的同工型，其表达分析使其功能无法解析。 Per在强硬体腺体中的表达分析表明，该器官重要参与了中央交叉起搏器在视交叉上核的稳定和复位机制以及对地下生命的独特适应。

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