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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Recognition of the DNA sequence by an inorganic crystal surface
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Recognition of the DNA sequence by an inorganic crystal surface

机译：通过无机晶体表面识别DNA序列

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摘要

The sequence-dependent curvature is generally recognized as an important and biologically relevant property of DNA because it is involved in the formation and stability of association complexes with proteins. When a DNA tract, intrinsically curved for the periodical recurrence on the same strand of A-tracts phased with the B-DNA periodicity, is deposited on a flat surface, it exposes to that surface either a T- or an A-rich face. The surface of a freshly cleaved mica crystal recognizes those two faces and preferentially interacts with the former one. Statistical analysis of scanning force microscopy (SFM) images provides evidence of this recognition between an inorganic crystal surface and nanoscale structures of double-stranded DNA. This finding could open the way toward the use of the sequence-dependent adhesion to specific crystal faces for nanotechnological purposes.
机译：依赖序列的曲率通常被认为是DNA的重要且生物学相关的性质，因为它参与了与蛋白质缔合复合物的形成和稳定性。当一个DNA束在平坦的表面上沉积时，由于固有的弯曲而周期性地重复出现在与B-DNA周期性相一致的A束同一条链上，因此该表面暴露出T或A富集的表面。新近切割的云母晶体的表面识别出这两个面，并优先与前一个相互作用。扫描力显微镜（SFM）图像的统计分析为无机晶体表面和双链DNA的纳米级结构之间的这种识别提供了证据。这一发现可能为纳米技术目的向特定晶体表面使用依赖序列的粘附开辟道路。

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