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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Chemotherapeutic hope on the horizon for Plasmodium vivax malaria?
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Chemotherapeutic hope on the horizon for Plasmodium vivax malaria?

机译:间日疟原虫疟疾的化学治疗希望即将到来?

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Plasmodium vivax malaria is less well reported and studied than the more virulent Plasmodium falciparum malaria, but it remains a cause of tremendous morbidity. Until recently, it was widely believed that this species was not susceptible to the dihydrofolate reductase (DHFR) inhibitors successfully utilized against P. falciparum such as pyrimeth-amine. However, several recent articles have challenged this concept. An article by Hastings and Sibley in a recent issue of PNAS adds to this work and brings additional perspectives on the future potential role of antifolates for P. vivax.
机译:间日疟原虫疟疾比毒性更大的恶性疟原虫疟疾的报道和研究较少,但它仍然是造成巨大发病的原因。直到最近,人们广泛认为,该物种对成功用于抗恶性疟原虫的乙氢叶酸还原酶(DHFR)抑制剂(如嘧啶胺)不敏感。但是,最近有几篇文章对这一概念提出了挑战。 Hastings和Sibley在最近一期的PNAS上发表的一篇文章增加了这项工作,并为抗叶酸药物在间日疟原虫的未来潜在作用中带来了新的见解。

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