Chaperoning brain degeneration

Nancy M. Bonini

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Chaperoning brain degeneration

机译：陪伴性脑退化

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Drosophila has emerged as a premiere model system for the study of human neurodegenerative disease. Genes associated with neu-rodegeneration can be expressed in flies, causing phenotypes remarkably similar to those of the counterpart human diseases. Because human neurodegenerative diseases, including Hunting-ton's and Parkinson's diseases, are disorders for which few cures or treatments are available, Drosophila brings to bear powerful genetics to the problem of these diseases. The molecular chaper-ones were the first modifiers defined that interfere in the progression of such disease phenotypes in Drosophila. Hsp70 is a potent suppressor of both polyglutamine disease and Parkinson's disease in Drosophila. These studies provide the promise of treatments for human neurodegeneration through the up-regulation of stress and chaperone pathways.

机译：果蝇已经成为研究人类神经退行性疾病的主要模型系统。与neu-rodegeneration相关的基因可以在果蝇中表达，导致表型与人类相应疾病的表型非常相似。由于人类的神经退行性疾病，包括亨廷顿氏病和帕金森氏病，是很少有治愈或治疗方法的疾病，果蝇为这些疾病的问题带来了强大的遗传学。分子伴侣是定义为干扰果蝇中此类疾病表型进展的第一个修饰子。 Hsp70是果蝇中聚谷氨酰胺病和帕金森氏病的有效抑制剂。这些研究通过上调应激和分子伴侣途径为人类神经退行性疾病的治疗提供了希望。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第12期|p.16407-16411|共5页
作者
Nancy M. Bonini;
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作者单位

Department of Biology, University of Pennsylvania, Howard Hughes Medical Institute, Philadelphia, PA 19104-6018;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. From the archives. Corticobasal degeneration. By WRG Gibb, PJ Luther and CD Marsden. Brain 1989: 112; 1171-1192 with Corticobasal degeneration. A clinical study of 36 cases. By JO Rinne, MS Lee, PD Thompson and CD Marsden. Brain 1994: 117; 1183-1196. [J] . Compston A Brain: A journal of neurology . 2010,第7期

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3. Spastic pseudosclerosis (cortico-pallido-spinal degeneration), by Charles Davison (New York), Brain 1932: 55; 247–264 and Severe dementia associated with bilateral symmetrical degeneration of the thalamus, by K. Stern (From the National Hospital, Queen Square, London), Brain 1939: 62; 157–171. [J] . Alastair Compston Brain . 2009,第10期

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4. The Characterization of Fe Concretions in the Human Brain Exhibiting Neuro-degeneration with Brain Iron Accumulation (NBIA) [C] . John McCarthy, Susan Hayflick, Alex Buxbaum Microscopy and microanalysis.;Microscopy and microanalysis. . -1

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5. Effects of Knocking Out RIC3 and TMEM35 Chaperones on ALPHA7 Nicotinic Receptor Receptors in Mouse Brains [D] . Deshpande, Anish R. 2020

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6. Colloquium Paper: Chaperoning brain degeneration [O] . Nancy M. Bonini 2002

机译：讨论会论文：陪伴性脑退化
7. Aggregates of RNA Binding Proteins and ER Chaperones Linked to Exosomes in Granulovacuolar Degeneration of the Alzheimer’s Disease Brain [O] . Alfred Yamoah, Priyanka Tripathi, Antonio Sechi, 2020

机译：RNA结合蛋白和ER伴侣的聚集在阿尔茨海默病脑的甘油核呋喃退化中与外来瘤相关联

Chaperoning brain degeneration

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