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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral inhibition in the mammalian olfactory bulb
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Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral inhibition in the mammalian olfactory bulb

机译:二尖瓣细胞外侧树突中动作电位的传播是递减的,并控制哺乳动物嗅球中的反复和侧向抑制

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摘要

In the mammalian main olfactory bulb (MOB), the release of glutamate from lateral dendrites of mitral cells onto the dendrites of granule cells evokes recurrent and lateral inhibition of mitral cell activity. Whole-cell voltage recordings in the mouse MOB in vivo and in vitro show that recurrent and lateral inhibition together control the number, duration. and onset of odor-evoked action potential (AP) firing in mitral cells. APs in mitral cells propagate into the lateral dendrites and evoke a transient increase in dendritic calcium concentration ([Ca~2+]), which is decremental with distance from the soma. and increases with AP number. These results suggest that the extent of AP propagation in lateral dendrites of mitral cells, along with the concomitant dendritic Ca~2+ transient, controls the amplitude of lateral and recurrent inhibition and thus is a critical determinant of odor-specific AP patterns in the MOB.
机译:在哺乳动物的主要嗅球(MOB)中,谷氨酸从二尖瓣细胞的侧向树突释放到颗粒细胞的树突上引起了二尖瓣细胞活性的反复和侧向抑制。小鼠MOB在体内和体外的全细胞电压记录表明,反复和侧向抑制共同控制着数目,持续时间。并在二尖瓣细胞中释放出诱发气味的动作电位(AP)。二尖瓣细胞中的AP传播到外侧树突中,并引起树突状钙浓度([Ca〜2 +])的瞬时增加,该浓度随与躯体距离的增加而减小。并且随着AP数量的增加而增加。这些结果表明,AP在二尖瓣细胞的侧向树突中的传播程度以及伴随的树突状Ca〜2 +瞬变,控制了侧向抑制和反复抑制的幅度,因此是MOB中气味特异性AP模式的关键决定因素。 。

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