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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans
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Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans

机译：秀丽隐杆线虫的发育和性别调控的基因表达谱的全基因组分析

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摘要

We have constructed DNA microarrays containing 17,871 genes, representing about 94% of the 18.967 genes currently annotated in the Caenorhabditis elegans genome. These DNA microarrays can be used as a tool to define a nearly complete molecular profile of gene expression levels associated with different developmental stages, growth conditions, or worm strains. Here, we used these full-genome DNA microarrays to show the relative levels of gene expression for nearly every gene during development. from eggs through adulthood. These expression data can help reveal when a gene may act during development. We also compared gene ex- pression in males to that of hermaphrodites and found a total of 2,171 sex-regulated genes (P < 0.05). The sex-regulated genes provide a global view of the differences between the sexes at a molecular level and identify many genes likely to be involved in sex-specific differentiation and behavior.
机译：我们已经构建了包含17,871个基因的DNA微阵列，约占秀丽隐杆线虫基因组当前注释的18.967个基因的94％。这些DNA微阵列可以用作定义与不同发育阶段，生长条件或蠕虫菌株相关的基因表达水平的近乎完整的分子谱的工具。在这里，我们使用这些全基因组DNA微阵列来显示发育过程中几乎每个基因的相对基因表达水平。从卵到成年。这些表达数据可以帮助揭示基因在发育过程中何时起作用。我们还比较了男性和雌雄同体的基因表达，发现共有2,171个性别调控基因（P <0.05）。性别调控基因从分子水平提供了性别差异的全局视图，并鉴定了许多可能与性别特异性分化和行为有关的基因。

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