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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Arabidopsis genomes uncoupled 5 (GUN5) mutant reveals the involvement of Mg-chelatase H subunit in plastid-to-nucleus signal transduction
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Arabidopsis genomes uncoupled 5 (GUN5) mutant reveals the involvement of Mg-chelatase H subunit in plastid-to-nucleus signal transduction

机译：拟南芥基因组未偶联的5（GUN5）突变体揭示了Mg-螯合酶H亚基参与质体-核信号转导

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摘要

A plastid-derived signal plays an important role in the coordinated expression of both nuclear- and chloroplast-localized genes that encode photosynthesis-related proteins. Arabidopsis GUN (ge- nomes uncoupled) loci have been identified as components of plastid-to-nucleus signal transduction. Unlike wild-type plants, gun mutants have nuclear Lhcb1 expression in the absence of chloroplast development. We observed a synergistic phenotype in some gun double-mutant combinations, suggesting there are at least two independent pathways in plastid-to-nucleus signal trans- duction. There is a reduction of chlorophyll accumulation in gun4 and gun5 mutant plants, and a gun4gun5 double mutant shows an albino phenotype. We cloned the GUN5 gene. which encodes the ChlH subunit of Mg-chelatase. We also show that gun2 and gun3 are alleles of the known photomorphogenic mutants, hy1 and hy2. which are required for phytochromobilin synthesis from heme. These findings suggest that certain perturbations of the tetrapyr- role biosynthetic pathway generate a signal from chloroplasts that causes transcriptional repression of nuclear genes encoding plas- tid-localized proteins. The comparison of mutant phenotypes of gun5 and another Mg-chelatase subunit (ChlI) mutant suggests a specific function for CHlH protein in the plastid-signaling pathway.
机译：来自质体的信号在编码光合作用相关蛋白的核和叶绿体定位基因的协调表达中起重要作用。拟南芥GUN（基因组未偶联）位点已被鉴定为质体-核信号转导的组成部分。与野生型植物不同，枪突变体在不存在叶绿体发育的情况下具有核Lhcb1表达。我们在某些枪支双突变体组合中观察到协同表型，表明质体-核信号转导中至少有两个独立的途径。在gun4和gun5突变体植物中，叶绿素积累减少，而gun4gun5双突变体显示出白化病表型。我们克隆了GUN5基因。编码Mg螯合酶的ChlH亚基。我们还表明，gun2和gun3是已知的光形态发生突变体hy1和hy2的等位基因。从血红素合成植物生长素所必需的。这些发现表明，四吡咯作用生物合成途径的某些扰动会产生来自叶绿体的信号，该信号引起编码质粒定位蛋白的核基因的转录抑制。 Gun5和另一个Mg-螯合酶亚基（ChlI）突变体的突变表型的比较表明，质体信号通路中CHlH蛋白具有特定功能。

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