...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Eight novel families of miniature inverted repeat transposable elements in the African malaria mosquito, Anopheles gambiae
【24h】

Eight novel families of miniature inverted repeat transposable elements in the African malaria mosquito, Anopheles gambiae

机译：非洲疟疾蚊子冈比亚按蚊中的八个新的微型倒立重复重复转座因子家族

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Eight novel families of miniature inverted repeat transposable elements (MITEs) were discovered in the African malaria mosquito. Anopheles gambiae, by using new software designed to rapidly identify MITE-like sequences based on their structural characteris- tics. Divergent subfamilies have been found in two families. Past mobility was demonstrated by evidence of MITE insertions that resulted in the duplication of specific TA, TAA, or 8-bp targets. Some of these MITEs share the same target duplications and similar terminal sequences with MITEs and other DNA transposons in human and other organisms. MITEs in A. gambiae range from 40 to 1340 copies per genome, much less abundant than MITEs in the yellow fever mosquito. Aedes aegypti. Statistical analyses suggest that most A. gambiae MITEs are in highly AT-rich regions. many of which are closely associated with each other. The analyses of these novel MITEs underscored interesting questions regarding their diversity, origin, evolution. and relationships to the host genomes. The discovery of diverse families of MITEs in A. gambiae has important practical implications in light of current efforts to control malaria by replacing vector mosquitoes with genetically modified refractory mosquitoes. Finally. the systematic approach to rapidly identify novel MITEs should have broad applications for the anal- ysis of the ever-growing sequence databases of a wide range of organisms.
机译：在非洲疟疾蚊子中发现了八个新颖的微型反向重复转座因子（MITE）家族。冈比亚按蚊，通过使用新软件来设计，以根据其结构特征快速识别MITE样序列。在两个家庭中发现了不同的亚科。过去的流动性通过MITE插入的证据得以证明，该插入导致特定TA，TAA或8 bp目标的重复。这些MITE中的一些与人和其他生物中的MITE和其他DNA转座子具有相同的靶标重复和相似的末端序列。每个基因组中冈比亚按蚊的螨虫数量为40至1340个拷贝，比黄热蚊子中的螨虫数量少得多。埃及伊蚊。统计分析表明，大多数冈比亚按蚊（A. gambiae）MITE都位于AT含量很高的地区。其中许多彼此紧密相关。对这些新型MITE的分析强调了有关其多样性，起源，进化的有趣问题。以及与宿主基因组的关系。鉴于目前通过用遗传修饰的难治性蚊子替代病媒蚊子来控制疟疾的努力，在冈比亚按蚊中发现多种螨虫家族具有重要的实际意义。最后。快速鉴定新型MITE的系统方法应在分析日益增长的各种生物的序列数据库中得到广泛应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号