C~mC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing

Cindy Sue Malone; Maurine D. Miner; Jeanette R. Doerr

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C~mC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing

机译：C〜mC（A / T）GG DNA甲基化与成熟B细胞淋巴瘤基因沉默

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DNA methylation has been linked to gene silencing in cancer. Primary effusion lymphoma (PEL) and myeloma are lymphoid malignancies that arise from terminally differentiated B cells. Interestingly, PEL do not express immunoglobulins or most B lineage-specific genes. The B cell-specific B29 (Igβ/CD79b) gene is silenced in PEL and some myelomas but is expressed in other normal and malignant B cells. B29 expression was reactivated in PEL by demethylating and histone deacetylase inhibiting treat- ments. Bisulfite sequencing revealed two types of DNA meth- ylation in silenced B29 promoters: at conventional CpG and at CC(A/T)GG B29 promoter sites.

机译：DNA甲基化与癌症中的基因沉默有关。原发性积液性淋巴瘤（PEL）和骨髓瘤是由终末分化B细胞引起的淋巴样恶性肿瘤。有趣的是，PEL不表达免疫球蛋白或大多数B谱系特异性基因。 B细胞特异性B29（Igβ/ CD79b）基因在PEL和一些骨髓瘤中沉默，但在其他正常和恶性B细胞中表达。通过去甲基化和抑制组蛋白脱乙酰基酶处理，P29中的B29表达被重新激活。亚硫酸氢盐测序揭示了沉默的B29启动子中两种类型的DNA甲基化：在常规CpG和CC（A / T）GG B29启动子位点。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第18期|p.10404-10409|共6页
作者
Cindy Sue Malone; Maurine D. Miner; Jeanette R. Doerr;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. C~mC(a/t)GG methylation: A new epigenetic mark in mammalian DNA? [J] . Matthew C. Lorincz, Mark Groudine Proceedings of the National Academy of Sciences of the United States of America . 2001,第18期

机译：C〜mC（a / t）GG甲基化：哺乳动物DNA中的新表观遗传标记？
2. DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas [J] . Anne Y. Lai, Mehrnaz Fatemi, Archana Dhasarathy, The Journal of Experomental Medicine . 2010,第9期

机译：DNA甲基化可防止CTCF介导的B细胞淋巴瘤癌基因BCL6沉默
3. Patterned CpG Methylation of Silenced B Cell Gene Promoters in Classical Hodgkin Lymphoma-derived and Primary Effusion Lymphoma Cell Lines. [J] . Doerr JR, Malone CS, Fike FM, Journal of Molecular Biology . 2005,第4期

机译：在经典霍奇金淋巴瘤来源的和原发性渗出性淋巴瘤细胞系中沉默的B细胞基因启动子的模式CpG甲基化。
4. Genes associated with genotype-specific DNA methylation in squamous cell carcinoma as candidate drug targets [C] . Ryoichi Kinoshita, Mitsuo Iwadate, Hideaki Umeyama, Asia-Pacific Bioinformatics Conference . 2014

机译：与鳞状细胞癌中基因型特异性DNA甲基化相关的基因作为候选药物靶标
5. DNMT3B7, a truncated DNMT3B protein found in cancer cells, disrupts murine embryonic development and alters DNA methylation in myc-induced lymphomas. [D] . Shah, Mrinal Y. 2010

机译：DNMT3B7是在癌细胞中发现的一种截短的DNMT3B蛋白，可破坏鼠类胚胎的发育并改变myc诱导的淋巴瘤中的DNA甲基化。
6. CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing [O] . Cindy Sue Malone, Maurine D. Miner, Jeanette R. Doerr, 2001

机译：CmC（A / T）GG DNA甲基化与成熟B细胞淋巴瘤基因沉默
7. CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing [O] . Malone, Cindy Sue, Miner, Maurine D., Doerr, Jeanette R., 2001

机译：CmC（A / T）GG DNA甲基化与成熟B细胞淋巴瘤基因沉默

C~mC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing

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