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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Crosstalk of the group IIa and IIb metals calcium and zinc in cellular signaling
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Crosstalk of the group IIa and IIb metals calcium and zinc in cellular signaling

机译:细胞信号传导中IIa和IIb组金属钙和锌的串扰

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摘要

Life has harnessed the functional poten- tial of many metal ions and thereby bridged the boundaries between organic and inorganic chemistry. A case in point here is zinc, which is essential for growth and development. As a constituent of pro- teins, zinc performs critical cellular func- tions (1). Its great versatility in catalysis is used in hundreds of enzymes of all six classes (2). In zinc finger proteins--a ge- neric term for several coordination types in thousands of proteins--it has primarily a structural role in organizing protein domains for the recognition of other pro- teins, nucleic acids, and lipids (3,4).
机译:生命利用了许多金属离子的功能潜能,从而架起了有机和无机化学之间的界限。锌就是一个很好的例子,锌对于生长和发育至关重要。锌作为蛋白质的组成部分,具有重要的细胞功能(1)。它在催化中的多功能性可用于所有六类酶中的数百种(2)。在锌指蛋白中(数千种蛋白中几种协调类型的总称),它在组织蛋白域以识别其他蛋白,核酸和脂质方面起主要结构性作用(3,4) 。

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