Genetically engineered macrophages expressing IFN-γ restore alveolar immune function in scid mice

Min Wu; Shabbir Hussain; Ying-Hui He

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Genetically engineered macrophages expressing IFN-γ restore alveolar immune function in scid mice

机译：表达IFN-γ的基因工程巨噬细胞可恢复scid小鼠的肺泡免疫功能

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Reversal of immunodeficiency in the lung by gene therapy is limited in part by the difficulty of transfecting lung cells in vivo. Many options exist for successfully transfecting cells in vitro, but they are not easily adapted to the in vivo condition. To overcome this limitation, we transduced macrophages in vitro with the murine IFN-γ (mIFN-γ) gene and intratracheally delivered the macrophages to express mIFN-γ in vivo. A recombinant retroviral vector pSF91 system was modified to encode mIFN-γ and enhanced green fluorescent protein (EGFP). A murine macrophage cell line J774A.

机译：通过基因疗法逆转肺部免疫缺陷会部分受限于体内转染肺细胞的困难。存在许多用于在体外成功转染细胞的选择，但是它们不容易适应体内条件。为了克服此限制，我们在体外用鼠IFN-γ（mIFN-γ）基因转导了巨噬细胞，并在气管内递送了巨噬细胞以在体内表达mIFN-γ。重组逆转录病毒载体pSF91系统进行了修改，以编码mIFN-γ和增强的绿色荧光蛋白（EGFP）。鼠巨噬细胞系J774A。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第25期|p.14589-14594|共6页
作者
Min Wu; Shabbir Hussain; Ying-Hui He;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Morphologic Detection and Functional Assessment of Reconstituted Normal Alveolar Macrophages in the Lungs of SCID Mice. [J] . Pasula R, Weaver T, Martinez MA, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2002,第8期

机译：SCID小鼠肺中重构的正常肺泡巨噬细胞的形态学检测和功能评估。
2. Morphologic Detection and Functional Assessment of Reconstituted Normal Alveolar Macrophages in the Lungs of SCID Mice [J] . Rajamouli Pasula, Todd Weaver, Manuel A. Martinez, The journal of immunology . 2002,第8期

机译：SCID小鼠肺中重组正常肺泡巨噬细胞的形态学检测和功能评估
3. Morphologic Detection and Functional Assessment of Reconstituted Normal Alveolar Macrophages in the Lungs of SCID Mice [J] . Rajamouli Pasula, Todd Weaver, Manuel A. Martinez, The journal of immunology . 2002,第8期

机译：SCID小鼠肺中重组正常肺泡巨噬细胞的形态学检测和功能评估
4. Subcutaneous transplantation of reconstituted pseudo-islets to restore normoglycemia in diabetic SCID/bg mice [C] . Alexander E. Vlahos, Sara Keshavjee, Sean Kinney, Society for Biomaterials annual meeting and exposition . 2018

机译：重建的假胰岛皮下移植以恢复糖尿病SCID / bg小鼠的正常血糖
5. Immune functions of alveolar macrophages and peripheral blood monocytes in patients with lung cancer: Studies of local versus systemic immunity [D] . Siziopikou, Kalliopi P. 1991

机译：肺癌患者肺泡巨噬细胞和外周血单核细胞的免疫功能：局部和全身免疫研究
6. Genetically engineered macrophages expressing IFN-γ restore alveolar immune function in scid mice [O] . Min Wu, Shabbir Hussain, Ying-Hui He, 2001

机译：基因工程巨噬细胞表达IFN-γ恢复 scid小鼠的肺泡免疫功能
7. Genetically engineered macrophages expressing IFN-γ restore alveolar immune function in scid mice [O] . Wu, Min, Hussain, Shabbir, He, Ying-Hui, 2001

机译：基因工程巨噬细胞表达IFN-γ恢复 scid小鼠的肺泡免疫功能
8. Anthrax Lethal Toxin Impairs Innate Immune Functions of Alveolar Macrophages and Facilitates Bacillus anthracis Survival [R] . Ribot, W. J. , Panchal, R. G. , Brittingham, K. C. , 2006

机译：炭疽致死毒素损害肺泡巨噬细胞的先天免疫功能，促进炭疽杆菌存活

Genetically engineered macrophages expressing IFN-γ restore alveolar immune function in scid mice

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