Progress in transthyretin fibrillogenesis research strengthens the amyloid hypothesis

Avijit Chakrabartty

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Progress in transthyretin fibrillogenesis research strengthens the amyloid hypothesis

机译：运甲状腺素蛋白原纤维形成研究的进展加强了淀粉样蛋白假说

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The amyloidoses are diseases of protein conformation, in which a particular soluble innocuous protein transforms and aggregates into an insoluble fibrillar struc- ture that deposits in extracellular spaces of specific organs (reviewed in refs. 1-4). Organ dysfunction accompanies fibrillar deposition, and the amyloid hypothesis proposes a cause and effect relationship between deposition and dysfunction (re- viewed in refs. 4-7). Transthyretin (TTR) is one of 20 proteins that are known currently to form fibrillar deposits in hu- man amyloidoses (1,8).

机译：淀粉样蛋白是蛋白质构象的疾病，其中特定的可溶性无毒蛋白质转化并聚集为不溶性纤维状结构，该结构沉积在特定器官的细胞外空间中（参见参考文献1-4）。器官功能障碍伴随着原纤维沉积，淀粉样蛋白假说提出了沉积与功能障碍之间的因果关系（参见参考文献4-7）。运甲状腺素蛋白（TTR）是目前已知在人淀粉样蛋白中形成纤维状沉积物的20种蛋白之一（1,8）。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第26期|p.14757-14759|共3页
作者
Avijit Chakrabartty;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils. [J] . Cardoso I, Goldsbury CS, Muller SA, Journal of Molecular Biology . 2002,第5期

机译：运甲状腺素蛋白原纤维形成需要单体的组装：体外组装的运甲状腺素蛋白淀粉样样原纤维的分子模型。
2. Kinetic assay for high-throughput screening of in vitro transthyretin amyloid fibrillogenesis inhibitors [J] . Dolado I, Nieto J, Saraiva MJM, Journal of combinatorial chemistry . 2005,第2期

机译：高通量筛选体外运甲状腺素蛋白淀粉样蛋白原纤维形成抑制剂的动力学分析
3. Search for intermediate structures in transthyretin fibrillogenesis: Soluble tetrameric Tyr78Phe TTR expresses a specific epitope present only in amyloid fibrils [J] . Redondo C., Olofsson A., Lundgren E., Journal of Molecular Biology . 2000,第3期

机译：寻找运甲状腺素蛋白原纤维形成的中间结构：可溶性四聚体Tyr78Phe TTR表达仅存在于淀粉样蛋白原纤维中的特定表位
4. Impact of Genealogical Features in Transthyretin Familial Amyloid Polyneuropathy Age of Onset Prediction [C] . Maria Pedroto, Alípio Jorge, Jo?o Mendes-Moreira, International Conference on Practical Applications of Computational Biology and Bioinformatics . 2019

机译：基因特征在ransthyretin家族淀粉样蛋白的发病预测时代的影响
5. The Competing Physiological Roles of Transthyretin and Mechanistic Insight into Transthyretin-Mediated Inhibition of Beta-Amyloid Aggregation [D] . Mangrolia, Parth Vinod. 2018

机译：运甲状腺素蛋白的竞争性生理作用和对运甲状腺素蛋白介导的β-淀粉样蛋白聚集抑制的机理研究。
6. Progress in transthyretin fibrillogenesis research strengthens the amyloid hypothesis [O] . Avijit Chakrabartty 2001

机译：运甲状腺素蛋白原纤维形成研究的进展加强淀粉样假说
7. Progress in transthyretin fibrillogenesis research strengthens the amyloid hypothesis [O] . Chakrabartty, Avijit 2001

机译：运甲状腺素蛋白原纤维形成研究的进展加强淀粉样假说

Progress in transthyretin fibrillogenesis research strengthens the amyloid hypothesis

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