An artificial transcriptional activating region with unusual properties

Xiangyang Lu; Aseem Z. Ansari; Mark Ptashnet

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An artificial transcriptional activating region with unusual properties

机译：具有异常特性的人工转录激活区

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We describe a series of transcriptional activators generated by adding amino acids (eight in one case, six in another) to fragments of the yeast Saccharomyces cerevisiae activator Ga14 that dimerize and bind DNA. One of the novel activating regions identified by this procedure is unusual compared with previously characterized yeast activating regions, in the following ways: it works more strongly than does Gal4's natural activating region as assayed in yeast: it is devoid of acidic residues: and several lines of evidence suggest that it sees targets in the yeast transcriptional machinery at least partially distinct from those seen by GaI4's activating region.

机译：我们描述了通过将氨基酸（一种情况下为8种，另一种情况下为6种）添加到酵母酿酒酵母激活剂Ga14的片段中而产生的一系列转录激活剂，该片段使二聚并结合DNA。与以前表征的酵母激活区相比，通过该程序鉴定出的新型激活区之一在以下方面与众不同：与酵母中检测到的Gal4天然激活区相比，它的作用更强：它不含酸性残基：证据表明，它在酵母转录机制中看到的靶标至少部分不同于GaI4激活区所见的靶标。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2000年第5期|p.1988-1992|共5页
作者
Xiangyang Lu; Aseem Z. Ansari; Mark Ptashnet;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Transcriptional Regulation of the MHC Class II Trans-Activator (CIITA) Promoter III: Identification of a Novel Regulatory Region in the 5′-Untranslated Region and an Important Role for cAMP-Responsive Element Binding Protein 1 and Activating Transcription Factor-1 in CIITA-Promoter III Transcriptional Activation in B Lymphocytes [J] . Nienke van der Stoep, Edwin Quinten, Peter J. van den Elsen The journal of immunology . 2002,第9期

机译：MHC II类反式激活子（CIITA）启动子III的转录调控：5'-非翻译区的新型调控区的鉴定以及cAMP-响应元件结合蛋白1和激活转录因子1在CIITA-中的重要作用B淋巴细胞中的启动子III转录激活
2. Transcriptional Regulation of the MHC Class II Trans-Activator (CIITA) Promoter III: Identification of a Novel Regulatory Region in the 5′-Untranslated Region and an Important Role for cAMP-Responsive Element Binding Protein 1 and Activating Transcription Factor-1 in CIITA-Promoter III Transcriptional Activation in B Lymphocytes [J] . Nienke van der Stoep, Edwin Quinten, Peter J. van den Elsen The journal of immunology . 2002,第9期

机译：MHC II类反式激活子（CIITA）启动子III的转录调控：5'-非翻译区的新型调控区的鉴定以及cAMP-响应元件结合蛋白1和激活转录因子1在CIITA-中的重要作用B淋巴细胞中的启动子III转录激活
3. Structural analysis of the transcriptional activation region on Fis: Crystal structures of six Fis mutants with different activation properties [J] . Cheng YS., Johnson RC., Yuan HS., Journal of Molecular Biology . 2000,第5期

机译：Fis转录激活区的结构分析：六个具有不同激活特性的Fis突变体的晶体结构
4. In-depth activated transcription factor profiling with a concatenated tandem array of transcription factor response elements [C] . Chen Ding, Wanlin Liu, Dong Li, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：深入活化的转录因子分布，转录因子响应元件的连接串联阵列
5. I. Methodology development for the synthesis of geminally disubstituted beta-amino acids, beta-proline analogs and allylic amines. II. Progress towards the synthesis of an artificial transcription activator . [D] . Chen, Bin. 2005

机译：I.用于合成双取代的β-氨基酸，β-脯氨酸类似物和烯丙基胺的方法学发展。二。合成人工转录激活剂的研究进展。
6. An artificial transcriptional activating region with unusual properties [O] . Xiangyang Lu, Aseem Z. Ansari, Mark Ptashne 2000

机译：具有异常特性的人工转录激活区
7. An artificial transcriptional activating region with unusual properties [O] . Lu, Xiangyang, Ansari, Aseem Z., Ptashne, Mark 2000

机译：具有异常特性的人工转录激活区

An artificial transcriptional activating region with unusual properties

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