...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis
【24h】

Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis

机译：Mik1水平在S期积累，并可能介导S期与有丝分裂之间的内在联系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Two paradigms exist for maintaining order during cell-cycle pro- gression: intrinsic controls, where passage through one part of the cell cycle directly affects the ability to execute another. and checkpoint controls, where external pathways impose order in response to aberrant structures. By studying the mitotic inhibitor Mik1, we have identified evidence for an intrinsic link between unperturbed S phase and mitosis. We propose a model in which SlM linkage can be generated by the production and stabilization of Mik1 protein during S phase. The production of Mik1 during unperturbed S phase is independent of the Rad3- and Cds1- dependent checkpoint controls. In response to perturbed S phase, Rad3-Cds1 checkpoint controls are required to maintain high levels 0f Mik1, probably indirectly by extending the S phase period. where Mik1 is stable. In addition, we find that Mik1 protein can be moderately induced in response to irradiation of G2 cells in a Chk1-dependent manner.
机译：存在两种在细胞周期进程中维持秩序的范式：内在控制，通过细胞周期的一部分直接影响执行另一部分的能力。和检查点控制，其中外部路径根据异常结构施加顺序。通过研究有丝分裂抑制剂Mik1，我们已经确定了不受干扰的S期与有丝分裂之间存在内在联系的证据。我们提出了一个模型，其中SlM连锁可以通过在S期产生和稳定Mik1蛋白来产生。在不受干扰的S阶段，Mik1的产生独立于Rad3和Cds1依赖的检查点控件。为了响应受干扰的S阶段，可能需要通过延长S阶段周期间接地将Rad3-Cds1检查点控件维持在0f Mik1的高电平。 Mik1稳定的地方。此外，我们发现，Mik1蛋白可以以依赖Chk1的方式响应G2细胞的辐射而被适度诱导。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号