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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carclnoma cells
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Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carclnoma cells

机译：人树突状细胞与乳腺癌细胞的融合激活抗肿瘤细胞毒性T淋巴细胞

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摘要

We have reported that fusions of murine dendritic cells (DCs) and murine carcinoma cells reverse unresponsiveness to tumor-associ- ated antigens and induce the rejection of established metastases. In the present study, fusions were generated with primary human breast carcinoma cells and autologous DCs. Fusion cells coex- pressed tumor-associated antigens and DC-derived costimulatory molecules. The fusion cells also retained the functional potency of DCs and stimulated autologous T cell proliferation. Significantly, the results show that autologous T cells are primed by the fusion tells to induce MHC class l-dependent lysis of autologous breast tumor cells. These findings demonstrate that fusions of human breast cancer cells and DCs activate T cell responses against autologous tumors.
机译：我们已经报道鼠类树突状细胞（DC）和鼠类癌细胞的融合逆转了对肿瘤相关抗原的无反应性，并诱导了已建立的转移的排斥。在本研究中，与原代人乳腺癌细胞和自体DC融合。融合细胞共表达肿瘤相关抗原和DC衍生的共刺激分子。融合细胞还保留了DC的功能效能，并刺激了自体T细胞增殖。显着地，结果表明融合引发了自体T细胞的分化，诱导了自体乳腺肿瘤细胞的MHC I类依赖性裂解。这些发现证明人乳腺癌细胞和DC的融合激活了针对自体肿瘤的T细胞应答。

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