Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach

Julie Talon; Mirella Salvatore; Robert E. ONeill

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Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach

机译：表达改变的NS1蛋白的甲型和乙型流感病毒：一种疫苗方法

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We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type l IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza A virus possesses anti-IFN activity. We now present evidence that influenza A and B viruses encoding altered viral NS1 proteins are highly attenuated in the mouse host, yet provide protection from challenge with wild-type viruses.

机译：我们提出了一种产生活病毒疫苗的合理方法：改变病毒编码的l型IFN拮抗剂以减弱毒力，同时保留免疫原性。我们已经通过使用流感病毒探索了这个概念。以前我们已经证明甲型流感病毒的NS1蛋白具有抗IFN活性。我们现在提供证据表明，编码改变的病毒NS1蛋白的甲型和乙型流感病毒在小鼠宿主中高度减毒，但却提供了免受野生型病毒攻击的保护。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2000年第8期|p.4309-4314|共6页
作者
Julie Talon; Mirella Salvatore; Robert E. ONeill;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：犬流感病毒与改性NS1蛋白的发育，用于开发活衰减的疫苗
2. Influenza Viral Vectors Expressing Two Kinds of HA Proteins as Bivalent Vaccine Against Highly Pathogenic Avian Influenza Viruses of Clade 2.3.4.4 H5 and H7N9 [J] . Jinping Li, Guangyu Hou, Yan Wang, Frontiers in Microbiology . 2018,第6期

机译：流感病毒载体表达两种HA蛋白作为针对进化枝2.3.4.4 H5和H7N9的高致病性禽流感病毒的二价疫苗
3. Influenza Viral Vectors Expressing Two Kinds of HA Proteins as Bivalent Vaccine Against Highly Pathogenic Avian Influenza Viruses of Clade 2.3.4.4 H5 and H7N9 [J] . Jinping Li, Guangyu Hou, Yan Wang, Frontiers in Microbiology . 2018,第6期

机译：流感病毒载体表达两种HA蛋白作为针对进化枝2.3.4.4 H5和H7N9的高致病性禽流感病毒的二价疫苗
4. Single-Cell Approach in Influenza Vaccine Production: Apoptosis and Virus Protein Production [C] . Josef Scjiulze-Horsel, Mareike Schulze, Yvonne Genzel, European Society of Animal Cell Technology . 2010

机译：流感疫苗生产中的单细胞方法：凋亡和病毒蛋白质生产
5. Role and importance of NS1 protein of avian influenza virus to grow in the presence of interferon and evaluation of the NS1 mutant viruses as potential DIVA vaccines. [D] . Brahmakshatriya, Vinayak R. 2009

机译：禽流感病毒NS1蛋白在干扰素存在下的生长作用和重要性，以及对NS1突变病毒作为潜在DIVA疫苗的评价。
6. Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach [O] . Julie Talon, Mirella Salvatore, Robert E. ONeill, 2000

机译：表达改变的NS1蛋白的甲型和乙型流感病毒：一种疫苗方法
7. Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach [O] . Talon, Julie, Salvatore, Mirella, O'Neill, Robert E., 2000

机译：表达改变的NS1蛋白的甲型和乙型流感病毒：一种疫苗方法

Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach

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