Plasticity in the organization and sequences of human KIR/ILT gene families

Michael J. Wilson; Michaela Torkar; Anja Haude

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Plasticity in the organization and sequences of human KIR/ILT gene families

机译：人类KIR / ILT基因家族的组织和序列的可塑性

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The ≈1-Mb leukocyte receptor complex at 19q13.4 is a key polymor- phic immunoregion containing all of the natural killer-receptor KIR and related ILT genes. When the organization of the leukocyte receptor complex was compared from two haplotypes, the gene content in the KIR region varied dramatically, with framework loci flanking regions of widely variable gene content. The ILT-genes were more stable in number except for ILr6, which was present only in one haplotype. Analysis of ALu repeats and comparison of KIR gene sequences, which are over 90/100 identical. are consistent with a recent origin. KIR genesis was followed by extensive duplication/deletion as well as intergenic sequence exchange. reminiscent of MHC class Ⅰ genes, which provide KIR ligands.

机译：位于19q13.4处的≈1-Mb白细胞受体复合物是关键的多形免疫区域，包含所有自然杀伤受体KIR和相关的ILT基因。当从两种单倍型中比较白细胞受体复合物的组织时，KIR区的基因含量变化很大，框架基因座侧翼区的基因含量变化很大。除了仅在一种单倍型中存在的ILr6，ILT基因在数量上更稳定。 ALu重复序列的分析和KIR基因序列的比较（超过90/100相同）。与最近的来历一致。 KIR发生之后是广泛的复制/删除以及基因间的序列交换。让人想起提供KIR配体的MHCⅠ类基因。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2000年第9期|p.4778-4783|共6页
作者
Michael J. Wilson; Michaela Torkar; Anja Haude;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex [J] . Neil T. Young, Flavio Canavez, Markus Uhrberg, Immunogenetics . 2001,第4期

机译：ILT / LIR基因家族在多态性人类白细胞受体复合物中的保守组织
2. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues [J] . Graeme I. Bell, Jun Takeda, Susumu Seino Nucleic acids research . 1992,第17期

机译：人Oct3基因家族：cDNA序列，其他剪接，基因组织，染色体位置和在成人组织中的低水平表达
3. Complete characterization of killer Ig-like receptor (KIR) haplotypes in Mauritian cynomolgus macaques: novel insights into nonhuman primate KIR gene content and organization. [J] . Bimber BN, Moreland AJ, Wiseman RW, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2008,第9期

机译：毛里求斯猕猴的杀伤性Ig样受体（KIR）单倍型的完整表征：对非人类灵长类KIR基因含量和组织的新见解。
4. Organizational Heterogeneity of the Human Genome: Significant Variation of Recombination Rate of 100 kbp Sequences within GC Ranges [C] . Svetlana Frenkel, Valery Kirzhner, Zeev Frenkel, 2016 Second International Symposium on Stochastic Models in Reliability Engineering, Life Science and Operations Management . 2016

机译：人类基因组的组织异质性：GC范围内100 kbp序列的重组速率的显着变化
5. Exploring the inhibition of human natural killer cells: Co-operation of KIR and ILT2. [D] . Kirwan, Sheryl Elaine. 2007

机译：探索抑制人类自然杀伤细胞：KIR和ILT2的合作。
6. Plasticity in the organization and sequences of human KIR/ILT gene families [O] . Michael J. Wilson, Michaela Torkar, Anja Haude, 2000

机译：人类KIR / ILT基因家族的组织和序列的可塑性
7. Plasticity in the organization and sequences of human KIR/ILT gene families [O] . Wilson, Michael J., Torkar, Michaela, Haude, Anja, 2000

机译：人类KIR / ILT基因家族的组织和序列的可塑性
8. Genomic Characterization of KIR2DL4 in Families and Unrelated Individuals Reveals Extensive Diversity in Exon and Intron Sequences Including a Common Frameshift Variation Occurring in Several Alleles [R] . Gedil, M. A. , Steiner, N. K. , Hurley, C. K. 2005

机译：KIR2DL4在家族和无关个体中的基因组表征揭示外显子和内含子序列的广泛多样性，包括在几个等位基因中发生的共同移码变异

Plasticity in the organization and sequences of human KIR/ILT gene families

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