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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds
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Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds

机译：自组装肽支架上广泛的神经突增生和主动突触形成。

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摘要

A new type of self-assembling peptide (sapeptide) scaffolds that serve as substrates for neurite outgrowth and synapse formation is described. These peptide-based scaffolds are amenable to mo- lecular design by using chemical or biotechnological syntheses. They can be tailored to a variety of applications. The sapeptide scaffolds are formed through the spontaneous assembly of ionic self-complementary β-sheet oligopeptides under physiological conditions, producing a hydrogel material. The scaffolds can sup- port neuronal cell attachment and differentiation as well as ex- tensive neurite outgrowth. Furthermore, they are permissive sub- strates for functional synapse formation between the attached neurons. That primary rat neurons form active synapses on such scaffold surfaces in situ Suggests these scaffolds could be useful for tissue engineering applications. The buoyant sapeptide scaf- folds with attached cells in culture can be transported readily from one environment to another. Furthermore. these peptides did not elicit a measurable immune response or tissue inflammation when introduced into animals. These biological materials created through molecular design and self assembly may be developed as a biologically compatible scaffold for tissue repair and tissue engineering.
机译：描述了一种新型的自组装肽（sapeptide）支架，可作为神经突生长和突触形成的底物。这些基于肽的支架可通过使用化学或生物技术合成方法进行分子设计。它们可以针对各种应用进行定制。在生理条件下，通过自发组装离子型自互补β-折叠寡肽形成sapeptide支架，从而产生水凝胶材料。支架可以支持神经元细胞的附着和分化，以及广泛的神经突增生。此外，它们是附着神经元之间功能性突触形成的容许底物。原代大鼠神经元在此类支架表面上原位形成活性突触，表明这些支架可用于组织工程应用。培养中附着细胞的浮力肽肽可以很容易地从一种环境转移到另一种环境。此外。当引入动物体内时，这些肽不会引起可测量的免疫反应或组织发炎。通过分子设计和自组装产生的这些生物材料可以开发为生物相容的支架，用于组织修复和组织工程。

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