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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Decoupled evolution of coding region and mRNA expression patterns after gene duplication: Implications for the neutralist-selectionist debate
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Decoupled evolution of coding region and mRNA expression patterns after gene duplication: Implications for the neutralist-selectionist debate

机译：基因复制后编码区和mRNA表达模式的解耦进化：对中性选择主义辩论的启示

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摘要

The neutralist perspective on molecular evolution maintains that the vast majority of mutations affecting gene function are neutral or deleterious. After a gene duplication where both genes are retained, it predicts that original and duplicate genes diverge at clock-like rates. This prediction is usually tested for coding se- quences, but can also be applied to another important aspect of gene function, the genes' expression pattern. Moreover, if both sequence and expression pattern diverge at clock-like rates. a correlation between divergence in sequence and divergence in expression patterns is expected. Duplicate gene pairs with more highly diverged sequences should also show more highly diverged expression patterns. This prediction is tested for a large sample of duplicated genes in the yeast Saccharomyces cerevisiae, using both genome sequence and microarray expression data. Only a weak correlation is observed, suggesting that coding sequence and mRNA expression patterns of duplicate gene pairs evolve inde- pendently and at vastly different rates. Implications of this finding for the neutralist-selectionist debate are discussed.
机译：对分子进化的中性观点认为，影响基因功能的绝大多数突变是中性的或有害的。在两个基因都被保留的基因重复之后，它预测原始基因和重复基因以时钟状的速率发生分歧。通常会测试此预测的编码顺序，但也可以将其应用于基因功能的另一个重要方面，即基因的表达方式。而且，如果序列和表达模式都以类似时钟的速率发散。期望序列差异与表达模式差异之间的相关性。具有高度差异较大的序列的重复基因对也应显示较高差异的表达模式。使用基因组序列和微阵列表达数据，对啤酒酵母中大量重复基因的样本进行了此预测测试。观察到的相关性很弱，这表明重复基因对的编码序列和mRNA表达模式独立地并且以非常不同的速率进化。讨论了这一发现对中立选择主义辩论的影响。

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