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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates
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Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates

机译：脊椎动物脑中含二十二碳六烯酸的磷脂分子种类

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摘要

The fatty acid composition of phospholipids and the contents of docosahexaenoic acid (DHA)-containing diacyl phosphatidylcho- line and diacyl phosphatidylethanolamine molecular species were determined from brains of five fresh-water fish species from a boreal region adapted to 5℃, five fresh-water fish species from a temperate region acclimated to 5℃, five fresh-water fish species from a temperate region acclimated to 20℃, and three fresh water fish species from a subtropic region adapted to 25-26℃. as well as six mammalian species and seven bird species. There was little difference in DHA levels of fish brains from the different thermal environments, mammalian and bird brain phospholipids contained a few percentage points less DHA than those of the fish investigated. Molecular species of 22:6/ 22:6. 22:6/20:5, 22:6/20:4, 16:0/22:6, 18:0/22:6. and 18:1/22:6 were identified from all brain probes, and 16:0/22:6. 18:0/22:6, and 18:1/22:6 were the dominating species. Cold-water fish brains were rich in 18:1/22:6 diacyl phosphatidylethanolamine (and, to a lesser degree. in diacyl phosphatidylcholine), and its level decreased with increasing environmental/body tempera- ture. The ratio of 18:0/22:6 to 16:0/22:6 phosphatidylcholine and phosphatidylethanolamine was inversely related to body tem- perature. Phospholipid vesicles from brains of cold-acclimated fish were more fluid, as assessed by using a 1,6-diphenyl-1,3,5- hexatriene fluorescent probe, than those from bird brains, but the fluidities were almost equal at the respective body temper- atures. It is concluded that the relative amounts of these molecular species and their ratios to each other are the major factors contributing to the maintenance of proper fluidity rela- tionships throughout the evolutionary chain as well as helping to maintain important brain functions such as signal transduc- tion and membrane permeability.
机译：从适应于5℃的北方地区的5种淡水鱼类的大脑中，测定了5种淡水鱼类的大脑中磷脂的脂肪酸组成以及含有二十二碳六烯酸（DHA）的二酰基磷脂酰胆碱和二酰基磷脂酰乙醇胺分子的含量。温带地区的淡水鱼类适应温度为5℃，温带地区的5种淡水鱼类适应温度为20℃，亚热带地区的25种淡水鱼类适应温度为25-26℃。以及六个哺乳动物物种和七个鸟类物种。在不同的热环境下，鱼脑的DHA水平几乎没有差异，哺乳动物和鸟脑磷脂的DHA比所研究的鱼少了几个百分点。 22：6/22：6的分子种类。 22：6/20：5、22：6/20：4、16：0/22：6、18：0/22：6。和18：1/22：6从所有脑探针中都被识别出来，而16：0/22：6。 18：0/22：6和18：1/22：6是主要物种。冷水鱼脑富含18：1/22：6二酰基磷脂酰乙醇胺（二酰基磷脂酰胆碱含量较低），其含量随环境/体温的升高而降低。 18：0/22：6与16：0/22：6的磷脂酰胆碱和磷脂酰乙醇胺的比例与体温成反比。用1,6-二苯基-1,3,5-己三烯荧光探针评估，冷驯化鱼脑中的磷脂囊泡比鸟脑中的脂质囊泡流动性更高，但各个身体的流动性几乎相等温度。结论是，这些分子种类的相对数量及其彼此之间的比率是在整个进化链中维持适当的流动性关系以及有助于维持重要的脑功能（例如信号转导）的主要因素。和膜的渗透性。

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