Gender-specific frequency of background somatic mutations at the hypoxanthine phosphoribosyltransferase locus in cord blood T lymphocytes from preterm newborns

MAKOTO YOSHIOKA; PAMEILA M. VACEK; TINA POSENO

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Gender-specific frequency of background somatic mutations at the hypoxanthine phosphoribosyltransferase locus in cord blood T lymphocytes from preterm newborns

机译：早产儿脐血T淋巴细胞中次黄嘌呤磷酸核糖基转移酶基因座背景体细胞突变的性别特异性频率

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Limited information is available regarding the frequency, spectrum, and clinical relevance of somatic mutations in the developing fetus. The goal of this study was to determine somatic mutant frequencies (Mfs) at the hypoxanthine phospho- ribesyltransferase (HPRT) reporter gene in cord blood T lym- phocytes from preterm infants to gain insight into in utero mutational events. Mf determinations were made by using the HPRT T cell cloning assay on cord blood samples from 52 preterm infants. Natural logarithm Mfs (lnMfs) from preterm infants were compared with results from our database for full-term infants. Our analysis revealed higher lnMfs in cord blood T lymphocytes from preterm compared with full-term infants (P = 0.008). In addition, preterm females had signifi- cantly higher lnMfs compared with full-term females (P < 0.001), whereas preterm males wcre found to have significantly lower InMfs than preterm females (P = 0.005). Regression analyses also demonstrate a significant relationship between lnMf and gestational age for preterm females that does not exist for preterm males. These results demonstrate the gender-specific association between Mf and age in humans.

机译：关于发育中的胎儿中体细胞突变的频率，频谱和临床相关性的信息有限。这项研究的目的是确定早产婴儿脐带血T淋巴细胞中次黄嘌呤磷酸核糖基转移酶（HPRT）报告基因的体细胞突变频率（Mfs），以了解子宫内的突变事件。使用HPRT T细胞克隆测定法对52例早产儿的脐血样本进行Mf测定。将早产儿的自然对数Mfs（lnMfs）与我们的足月儿数据库的结果进行了比较。我们的分析显示，早产儿脐带血T淋巴细胞中的lnMfs比足月儿高（P = 0.008）。此外，早产女性的lnMfs明显高于足月女性（P <0.001），而早产男性wcre的InMfs明显低于早产女性（P = 0.005）。回归分析还表明，早产女性的lnMf与胎龄之间存在显着关系，而早产男性则不存在。这些结果证明了Mf与人类年龄之间的性别特定关联。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1999年第2期|586-591|共6页
作者
MAKOTO YOSHIOKA; PAMEILA M. VACEK; TINA POSENO;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Mutational spectra at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in T-lymphocytes of nonsmoking and smoking lung cancer patients. [J] . Hackman P, Hou SM, Nyberg F, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2000,第1期

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2. X-Ray Induced Mutation Frequency at the Hypoxanthine Phosphoribosyltransferase Locus in Clinically Relevant Radioresistant Cells [J] . Yoshikazu Kuwahara, Mehryar Habibi Roudkenar, Yusuke Urushihara, International Journal of Medical Physics, Clinical Engineering and Radiation Oncology . 2017,第4期

机译：X射线诱导次黄嘌呤磷酸核糖基转移酶基因在临床相关的抗辐射细胞中的突变频率。
3. Similarity of in vivo somatic mutations at an autosomal adenine phosphoribosyltransferase locus between T- and B-cells in human peripheral blood. [J] . Hakoda M, Kamatani N, Terai C, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1996,第1a2期

机译：人外周血中T细胞和B细胞之间常染色体腺嘌呤磷酸核糖转移酶基因座处的体内体细胞突变的相似性。
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5. Somatic mutation at the glycophorin A locus in human newborns: Statistical considerations and the effects of in utero exposures. [D] . Gordish, Heather Ann. 2002

机译：人类新生儿糖蛋白A位点的体细胞突变：统计学上的考虑和宫内暴露的影响。
6. Gender-specific frequency of background somatic mutations at the hypoxanthine phosphoribosyltransferase locus in cord blood T lymphocytes from preterm newborns [O] . Makoto Yoshioka, Pamela M. Vacek, Tina Poseno, 1999

机译：早产儿脐血T淋巴细胞中次黄嘌呤磷酸核糖基转移酶基因座背景体细胞突变的性别特异性频率
7. Gender-specific frequency of background somatic mutations at the hypoxanthine phosphoribosyltransferase locus in cord blood T lymphocytes from preterm newborns [O] . Yoshioka, Makoto, Vacek, Pamela M., Poseno, Tina, 1999

机译：早产儿脐血T淋巴细胞中次黄嘌呤磷酸核糖基转移酶基因座背景体细胞突变的性别特异性频率

Gender-specific frequency of background somatic mutations at the hypoxanthine phosphoribosyltransferase locus in cord blood T lymphocytes from preterm newborns

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