Retinoid X receptors are essential for early mouse development and placentogenesis

OLIIA WENDLING; PIERRE CHAMBON; MANUEL MARK

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Retinoid X receptors are essential for early mouse development and placentogenesis

机译：维甲酸X受体对于小鼠早期发育和胎盘生成至关重要

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Embryos carrying null mutations of both retinoid X receptors #alpha# and #beta# [RXR#alpha#~(-/-)/RXR#beta#~(-/-)mutants] were generated. These mutant embryos die between 9.5 and 10.5 days of gestation and display a wide range of abnormal- ities. The cause of the lethality appears to be the lack of formation of the labyrinthine zone of the chorioallantoic placenta. In a thorough analysis of mutant conceptuses, we establish that RXRs, through heterodimerization with reti- noic acid receptors, are essential for postimplantation embry- onic development before placentogenesis. RXRs are also es- sential for the formation of the chorioallantoic placenta, most probably through RXR/peroxisomal proliferator-activated receptor-#gamma# heterodimers. Interestingly, as a RXR Iigand ap- pears dispensable, placentogenesis must be controlled by a yet unknown hormonal ligand(s) activating the heterodimeriza- tion partner(s) of RXRs.

机译：产生了携带两个类视黄醇X受体＃alpha＃和＃beta＃[RXR＃alpha＃〜（-/-）/ RXR＃beta＃〜（-/-）突变体]的无效突变的胚胎。这些突变的胚胎在妊娠9.5至10.5天之间死亡，并表现出广泛的异常情况。致死性的原因似乎是绒毛膜尿囊胎盘的迷宫区缺乏形成。通过对突变概念的全面分析，我们发现，通过与视黄酸受体的异二聚化作用，RXR对于胎盘发生之前的植入后胚胎发育至关重要。 RXR对于绒膜尿囊胎盘的形成也是必不可少的，很可能是通过RXR /过氧化物酶体增殖物激活的受体-＃γ＃异二聚体形成的。有趣的是，随着RXR配体的出现，胎盘的形成必须由激活RXR异源二聚体的未知激素配体控制。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1999年第2期|547-551|共5页
作者
OLIIA WENDLING; PIERRE CHAMBON; MANUEL MARK;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: Important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid [J] . Ulven SM., Weedon MS., Landaas VO., Developmental biology . 2000,第2期

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2. The interphotoreceptor retinoid binding (IRBP) is essential for normal retinoid processing in cone photoreceptors. [J] . Parker RO, Crouch RK Advances in Experimental Medicine and Biology . 2010,第Null期

机译：受体间类视黄醇结合（IRBP）对于视锥细胞中正常类维生素A加工至关重要。
3. Differential Activation of Nuclear Receptors by Perfluorinated Fatty Acid Analogs and Natural Fatty Acids: A Comparison of Human, Mouse, and Rat Peroxisome Proliferator-Activated Receptor-α, -β, and -γ, Liver X Receptor-β, and Retinoid X Receptor-α [J] . John P. Vanden Heuvel, Jerry T. Thompson, Steven R. Frame† and Peter J. Gillies†‡ Toxicological Sciences . 2006,第2期

机译：全氟化脂肪酸类似物和天然脂肪酸对核受体的差异激活：人，小鼠和大鼠过氧化物酶体增殖物激活的受体-α，-β和-γ，肝X受体-β和类维生素A X受体-的比较α
4. Carotenoids and retinoids as suppressors on adipocyte differentiation via nuclear receptors [C] . Teruo Kawada, Yasutomi Kamei, Atsushi Fujita, International Conference on Food Factors . 2000

机译：Carotenoids和Retinoids作为抑制剂通过核受体分化的抑制剂
5. The Importance of Vitamin D, the Vitamin D Receptor (VDR) and Retinoid X Receptor Alpha (RXRalpha) in Murine Colitis Development and Progression. [D] . Knackstedt, Rebecca. 2013

机译：维生素D，维生素D受体（VDR）和类维生素X受体α（RXRalpha）在小鼠结肠炎发展和进展中的重要性。
6. Retinoid X receptors are essential for early mouse development and placentogenesis [O] . Olivia Wendling, Pierre Chambon, Manuel Mark 1999

机译：维甲酸X受体对于小鼠早期发育和胎盘生成至关重要
7. Retinoid X receptors are essential for early mouse development and placentogenesis [O] . Wendling, Olivia, Chambon, Pierre, Mark, Manuel 1999

机译：维甲酸X受体对于小鼠早期发育和胎盘生成至关重要

Retinoid X receptors are essential for early mouse development and placentogenesis

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