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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >MyoR: A muscle-restricted basic helix-loop-helix transcription factor that antagonizes the actions of MyoD
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MyoR: A muscle-restricted basic helix-loop-helix transcription factor that antagonizes the actions of MyoD

机译：MyoR：肌肉受限的基本螺旋-环-螺旋转录因子，可拮抗MyoD的作用

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摘要

Skeletal muscle development is controlled by a family of muscle-specific basic helix-loop-helix (bHLH) tran- scription factors that activate muscle genes by binding E-boxes (CANNTG) as heterodimers with ubiquitous bHLH proteins, called E proteins. Myogenic bHLH factors are expressed in proliferating undifferentiated myoblasts, but they do not initiate myogenesis until myoblasts exit the cell cycle. We describe a bHLH protein, MyoR (for myogenic repressor), that is expressed in undifferentiated myoblasts in culture and is down-regulated during differentiation. MyoR is also expressed specifically in the skeletal muscle lineage between days 10.5 and 16.5 of mouse embryogenesis and dowu-regulated thereafter during the period of secondary myogenesis. MyoR forms heterodimers with E proteins that bind the same DNA sequence as myogenic bHLH/E protein heterodimers, but MyoR acts as a potent transcriptional repressor that blocks myogenesis and activation of E-box- dependent muscle genes. These results suggest a role for MyoR as a lineage-restricted transcriptional repressor of the muscle differentiation program.
机译：骨骼肌的发育受一系列特定于肌肉的基本螺旋-环-螺旋（bHLH）转录因子的控制，这些因子通过将作为异二聚体的E-box（CANNTG）与普遍存在的bHLH蛋白（称为E蛋白）结合而激活肌肉基因。成肌bHLH因子在未分化的成肌细胞中表达，但直到成肌细胞退出细胞周期后，它们才启动成肌。我们描述了bHLH蛋白，MyoR（用于肌原性阻遏物），在文化中未分化的成肌细胞中表达，在分化过程中被下调。 MyoR在小鼠胚胎发生的第10.5至16.5天之间的骨骼肌谱系中也特异性表达，此后在继发性肌发生过程中受到dowu调节。 MyoR与E蛋白形成异源二聚体，该E蛋白与肌原性bHLH / E蛋白异源二聚体结合相同的DNA序列，但MyoR充当有效的转录阻遏物，阻断E-box依赖性肌肉基因的发生和激活。这些结果表明，MyoR作为肌肉分化程序的谱系限制转录阻遏物。

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