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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The effect of antibody-dependent enhancement on the transmission dynamics and persistence of multiple -strain pathogens
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The effect of antibody-dependent enhancement on the transmission dynamics and persistence of multiple -strain pathogens

机译：抗体依赖性增强对多株病原体传播动力学和持久性的影响

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摘要

Cross-reactive antibodies produced by a mammalian host during infection by a particular micropara- sitic strain usually have the effect of reducing the probability of the host being infected by a different, but closely related, pathogen strain. Such cross-reactive immunological re- sponses thereby induce between-strain competition within the pathogen population. However, in some cases such as dengue virus, evidence suggests that cross-reactive antibodies act to enhance rather than restrict the severity of a subsequent infection by another strain. This cooperative mechanism is thought to explain why pre-existing immunity to dengue virus is an important risk factor for the development of severe disease (i.e., dengue shock syndrome and dengue hemorrhagic fever). In this paper, we explore the effect of antibody- dependent enhancement on the transmission dynamics of multistrain pathogen populations. We show that enhancement frequently may generate complex and persistent cyclical or chaotic epidemic behavior. Furthermore, enhancement acts to permit the coexistence of all strains where in its absence only one or a subset would persist.
机译：哺乳动物宿主在感染特定微寄生虫菌株期间产生的交叉反应抗体通常具有降低宿主被另一种但密切相关的病原体菌株感染的可能性的作用。这样的交叉反应性免疫反应会引起病原体种群之间的菌株竞争。然而，在某些情况下，例如登革热病毒，证据表明交叉反应抗体可增强而不是限制随后被另一株感染的严重性。人们认为这种合作机制可以解释为什么对登革热病毒的预先存在的免疫力是发展严重疾病（即登革热休克综合征和登革热出血热）的重要危险因素。在本文中，我们探索了抗体依赖性增强对多菌株病原体种群传播动力学的影响。我们表明，增强经常会产生复杂且持续的周期性或混沌流行病行为。此外，增强作用允许所有菌株共存，而在不存在的情况下仅存在一个或一个子集。

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